Geoffrey Manley, MD, PhD

Professor and Vice Chairman of Neurological Surgery
Program Lead: Precision Neuroscience
Committee Members

Geoffrey T. Manley, MD, PhD is the Chief of Neurosurgery at San Francisco General Hospital and Professor of Neurosurgery at the University of California San Francisco (UCSF). He is a trauma neurosurgeon with clinical interests in brain injury, spinal cord injury and neurocritical critical care. His translational research interests span from the laboratory to the bedside.

Dr. Manley is a graduate of the Medical Scientist Training Program at Cornell University Medical College, where he earned his medical degree as well as his doctorate degree in Neuroscience. He completed his residency in Neurosurgery at UCSF and a Postdoctoral Fellowship in Molecular Biophysics. Dr. Manley is also a faculty member of the California Institute for Quantitative Biosciences and the UCSF Center for Clinical and Translational Informatics.

Dr. Manley is an internationally recognized expert in neurotrauma. He has published over 120 manuscripts that reflect a wide range of research interests from molecular aspects of brain injury to the clinical care of head trauma patients. He has helped to define new molecular mechanisms of injury to the nervous system that may lead to new treatments for these devastating injuries. He is also considered a leader in the rapidly growing field of advanced neuromonitoring and clinical informatics for critical care. His many honors include the General Motors Trauma Research Award and the Trauma Research Award from the American College of Surgeons. He has served as a Consultant for the Prehospital Guidelines Committee for the World Health Organization and on a number of committees for the National Institutes of Health.

Publications: 

Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study.

Neurology

Werner JK, Albrecht J, Capaldi VF, Jain S, Sun X, Mukherjee P, Williams SG, Collen J, Diaz-Arrastia R, Manley GT, Krystal AD, Wickwire E, TRACK-TBI Investigators

Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study.

Journal of neurosurgery

Yue JK, Lee YM, Sun X, van Essen TA, Elguindy MM, Belton PJ, Pisica D, Mikolic A, Deng H, Kanter JH, McCrea MA, Bodien YG, Satris GG, Wong JC, Ambati VS, Grandhi R, Puccio AM, Mukherjee P, Valadka AB, Tarapore PE, Huang MC, DiGiorgio AM, Markowitz AJ, Yuh EL, Okonkwo DO, Steyerberg EW, Lingsma HF, Menon DK, Maas AIR, Jain S, Manley GT, The TRACK-TBI Investigators

Diagnostic Utility of Glial Fibrillary Acidic Protein Beyond 12 Hours After Traumatic Brain Injury: A TRACK-TBI Study.

Journal of neurotrauma

Puccio AM, Yue JK, Korley FK, Okonkwo DO, Diaz-Arrastia R, Yuh EL, Ferguson AR, Mukherjee P, Wang KKW, Taylor S, Deng H, Markowitz AJ, Sun X, Jain S, Manley GT

Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A TRACK-TBI Study.

Journal of neurotrauma

Yue JK, Yuh EL, Elguindy MM, Sun X, Van Essen TA, Deng H, Belton PJ, Satris GG, Wong JC, Valadka A, Korley FK, Robertson CS, McCrea M, Stein MB, Diaz-Arrastia R, Wang KKW, Temkin N, DiGiorgio AM, Tarapore PE, Huang MC, Markowitz A, Puccio AM, Mukherjee P, Okonkwo DO, Jain S, Manley GT

MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline.

Neuroinformatics

Cai LT, Moon J, Camacho PB, Anderson AT, Chwa WJ, Sutton BP, Markowitz AJ, Palacios EM, Rodriguez A, Manley GT, Shankar S, Bremer PT, Mukherjee P, Madduri RK, TRACK-TBI Investigators

Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A TRACK-TBI Study.

JAMA surgery

Roberts CJ, Barber J, Temkin NR, Dong A, Robertson CS, Valadka AB, Yue JK, Markowitz AJ, Manley GT, Nelson LD, Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) Investigators, Badjatia N, Diaz-Arrastia R, Duhaime AC, Feeser VR, Gopinath S, Grandhi R, Jha R, Keene CD, Madden C, McCrea M, Merchant R, Ngwenya LB, Rodgers RB, Schnyer D, Taylor SR, Zafonte R

Network analysis and relationship of symptom factors to functional outcomes and quality of life following mild traumatic brain injury: a TRACK-TBI study.

Frontiers in neurology

Eagle SR, Jain S, Sun X, Preszler J, McCrea MA, Giacino JT, Manley GT, Okonkwo DO, Nelson LD, TRACK-TBI Investigators

Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning.

Scientific reports

Tritt A, Yue JK, Ferguson AR, Torres Espin A, Nelson LD, Yuh EL, Markowitz AJ, Manley GT, Bouchard KE, TRACK-TBI Investigators

Profiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers: A TRACK-TBI Study.

JAMA network open

Bryant AM, Rose NB, Temkin NR, Barber JK, Manley GT, McCrea MA, Nelson LD, TRACK-TBI Investigators, Badjatia N, Gopinath S, Keene CD, Madden C, Ngwenya LB, Puccio A, Robertson C, Schnyer D, Taylor SR, Yue JK

Association between Insomnia and Mental Health and Neurocognitive Outcomes Following Traumatic Brain Injury.

Journal of neurotrauma

Wickwire E, Albrecht JS, Capaldi VF, Jain S, Gardner RC, Smith MT, Williams S, Collen J, Schnyer DM, Giacino J, Nelson LD, Mukherjee P, Sun X, Werner K, Mosti C, Markowitz AJ, Manley GT, Krystal AD

Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study.

Annals of neurology

Snider SB, Temkin NR, Barber J, Edlow BL, Giacino JT, Hammond FM, Izzy S, Kowalski RG, Markowitz AJ, Rovito CA, Shih SL, Zafonte RD, Manley GT, Bodien YG, TRACK-TBI investigators

Safety and comparative efficacy of initiating low-molecular-weight heparin within 24 hours of injury or surgery for venous thromboembolism prophylaxis in patients with spinal cord injury: a prospective TRACK-SCI registry study.

Neurosurgical focus

Lui A, Park C, Chryssikos T, Radabaugh H, Patel A, Aabedi AA, Ferguson AR, Torres Espin A, Mummaneni PV, Dhall SS, Duong-Fernandez X, Saigal R, Chou A, Pan J, Singh V, Hemmerle DD, Kyritsis N, Talbott JF, Pascual LU, Huie JR, Whetstone WD, Bresnahan JC, Beattie MS, Weinstein PR, Manley GT, DiGiorgio AM

Longitudinal Recovery Following Repetitive Traumatic Brain Injury.

JAMA network open

Etemad LL, Yue JK, Barber J, Nelson LD, Bodien YG, Satris GG, Belton PJ, Madhok DY, Huie JR, Hamidi S, Tracey JX, Coskun BC, Wong JC, Yuh EL, Mukherjee P, Markowitz AJ, Huang MC, Tarapore PE, Robertson CS, Diaz-Arrastia R, Stein MB, Ferguson AR, Puccio AM, Okonkwo DO, Giacino JT, McCrea MA, Manley GT, Temkin NR, DiGiorgio AM, TRACK-TBI Investigators

Integrating, Harmonizing, and Curating Studies with High-Frequency and Hourly Physiological Data: Proof of Concept from Seven Traumatic Brain Injury Datasets.

Journal of neurotrauma

Yaseen A, Robertson CS, Cruz Navarro J, Chen J, Heckler B, DeSantis S, Temkin N, Barber J, Foreman B, Diaz-Arrastia RR, Chesnut RM, Manley GT, Wright D, Vassar M, Ferguson AR, Markowitz AJ, Yamal JM

Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study.

EClinicalMedicine

van Essen TA, van Erp IAM, Lingsma HF, Pisica D, Yue JK, Singh RD, van Dijck JTJM, Volovici V, Younsi A, Kolias A, Peppel LD, Heijenbrok-Kal M, Ribbers GM, Menon DK, Hutchinson PJA, Manley GT, Depreitere B, Steyerberg EW, Maas AIR, de Ruiter GCW, Peul WC, CENTER-TBI Investigators and Participants

Prevalence of and Risk Factors for Post-traumatic Headache in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study.

Mayo Clinic proceedings

Ashina H, Dodick DW, Barber J, Temkin NR, Chong CD, Adler JS, Stein KS, Schwedt TJ, Manley GT, TRACK-TBI Investigators

Long-term Multi-domain Patterns of Change Following Traumatic Brain Injury: A TRACK-TBI LONG Study.

Neurology

Brett BL, Temkin N, Barber JK, Okonkwo DO, Stein M, Bodien YG, Corrigan J, Diaz-Arrastia R, Giacino JT, McCrea MA, Manley GT, Nelson L, for TRACK-TBI Investigators

Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial.

Critical care (London, England)

Nordness MF, Maiga AW, Wilson LD, Koyama T, Rivera EL, Rakhit S, de Riesthal M, Motuzas CL, Cook MR, Gupta DK, Jackson JC, Williams Roberson S, Meurer WJ, Lewis RJ, Manley GT, Pandharipande PP, Patel MB

Examining later-in-life health risks associated with sport-related concussion and repetitive head impacts: a systematic review of case-control and cohort studies.

British journal of sports medicine

Iverson GL, Castellani RJ, Cassidy JD, Schneider GM, Schneider KJ, Echemendia RJ, Bailes JE, Hayden KA, Koerte IK, Manley GT, McNamee M, Patricios JS, Tator CH, Cantu RC, Dvorak J

Socioeconomic and clinical factors associated with prolonged hospital length of stay after traumatic brain injury.

Injury

Yue JK, Krishnan N, Chyall L, Vega P, Hamidi S, Etemad LL, Tracey JX, Tarapore PE, Huang MC, Manley GT, DiGiorgio AM

The American Congress of Rehabilitation Medicine Diagnostic Criteria for Mild Traumatic Brain Injury.

Archives of physical medicine and rehabilitation

Silverberg ND, Iverson GL, ACRM Brain Injury Special Interest Group Mild TBI Task Force and the ACRM Mild TBI Definition Expert, Cogan A, Dams-O'Connor K, Delmonico R, Graf MJP, Iaccarino MA, Kajankova M, Kamins J, McCulloch KL, McKinney G, Nagele D, Panenka WJ, Rabinowitz AR, Reed N, Wethe JV, Whitehair V, ACRM Mild TBI Diagnostic Criteria Expert Consensus Group, Anderson V, Arciniegas DB, Bayley MT, Bazarian JJ, Bell KR, Broglio SP, Cifu D, Davis GA, Dvorak J, Echemendia RJ, Gioia GA, Giza CC, Hinds SR, Katz DI, Kurowski BG, Leddy JJ, Sage NL, Lumba-Brown A, Maas AIR, Manley GT, McCrea M, Menon DK, Ponsford J, Putukian M, Suskauer SJ, van der Naalt J, Walker WC, Yeates KO, Zafonte R, Zasler ND, Zemek R

Associations of Microvascular Injury-Related Biomarkers with Traumatic Brain Injury Severity and Outcomes: A TRACK-TBI Pilot Study.

Journal of neurotrauma

Christman Schneider ALLC, Huie JR, Jain S, Sun X, Ferguson AR, Lynch CE, Yue JK, Manley GT, Wang KKW, Sandsmark D, Campbell C, Diaz-Arrastia RR

Managing outcome expectations after Traumatic Brain Injury.

Injury

Maas AIR, Hemphill JC, Wilson L, Manley GT

Prognostication and Withdrawal of Care Decisions in Severe Traumatic Brain Injury: A Survey of The Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) Working Group.

Journal of neurotrauma

Sarigul B, Bell RS, Chesnut RM, Aguilera S, Buki A, Citerio G, Cooper DJ, Diaz-Arrastia RR, Diringer M, Figaji A, Gao G, Geocadin R, Ghajar J, Harris OA, Hoffer A, Hutchinson PJ, Joseph M, Kitagawa RS, Manley GT, Mayer S, Menon D, Meyfroidt G, Michael D, Oddo M, Okonkwo DO, Patel MB, Robertson CS, Rosenfeld JV, Rubiano AM, Sahuquillo J, Servadei F, Shutter L, Stein D, Stocchetti N, Taccone F, Timmons S, Tsai E, Ullman JS, Vespa PM, Videtta W, Wright D, Zammit C, Hawryluk G

Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma.

The New England journal of medicine

Hutchinson PJ, Adams H, Mohan M, Devi BI, Uff C, Hasan S, Mee H, Wilson MH, Gupta DK, Bulters D, Zolnourian A, McMahon CJ, Stovell MG, Al-Tamimi YZ, Tewari MK, Tripathi M, Thomson S, Viaroli E, Belli A, King AT, Helmy AE, Timofeev IS, Pyne S, Shukla DP, Bhat DI, Maas AR, Servadei F, Manley GT, Barton G, Turner C, Menon DK, Gregson B, Kolias AG, British Neurosurgical Trainee Research Collaborative, NIHR Global Health Research Group on Acquired

Response to the Letter to the Editor by Dr. Michael Hutchinson re: NEU-2021-0408.R1.

Journal of neurotrauma

Mukherjee P, Palacios EM, Manley GT

Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study.

Neurotrauma reports

Yue JK, Kobeissy FH, Jain S, Sun X, Phelps RRL, Korley FK, Gardner RC, Ferguson AR, Huie JR, Schneider ALC, Yang Z, Xu H, Lynch CE, Deng H, Rabinowitz M, Vassar MJ, Taylor SR, Mukherjee P, Yuh EL, Markowitz AJ, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT, Wang KKW

A standardized postoperative bowel regimen protocol after spine surgery.

Frontiers in surgery

Yue JK, Krishnan N, Wang AS, Chung JE, Etemad LL, Manley GT, Tarapore PE

Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study.

Journal of neurosurgery. Spine

Agarwal N, Blitstein J, Lui A, Torres-Espin A, Vasnarungruengkul C, Burke J, Mummaneni PV, Dhall SS, Weinstein PR, Duong-Fernandez X, Chou A, Pan J, Singh V, Ferguson AR, Hemmerle DD, Kyritsis N, Talbott JF, Whetstone WD, Bresnahan JC, Beattie MS, Manley GT, DiGiorgio A

Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study.

medRxiv : the preprint server for health sciences

Snider SB, Temkin NR, Barber J, Edlow BL, Giacino JT, Hammond FM, Izzy S, Kowalski RG, Markowitz AJ, Rovito CA, Shih SL, Zafonte RD, Manley GT, Bodien YG, TRACK-TBI Investigators

Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study.

Journal of clinical medicine

Yue JK, Krishnan N, Kanter JH, Deng H, Okonkwo DO, Puccio AM, Madhok DY, Belton PJ, Lindquist BE, Satris GG, Lee YM, Umbach G, Duhaime AC, Mukherjee P, Yuh EL, Valadka AB, DiGiorgio AM, Tarapore PE, Huang MC, Manley GT, Investigators TT

Functional Recovery, Symptoms, and Quality of Life 1 to 5 Years After Traumatic Brain Injury.

JAMA network open

Nelson LD, Temkin NR, Barber J, Brett BL, Okonkwo DO, McCrea MA, Giacino JT, Bodien YG, Robertson C, Corrigan JD, Diaz-Arrastia R, Markowitz AJ, Manley GT, TRACK-TBI Investigators

Towards further progress in traumatic brain injury - Authors' reply.

The Lancet. Neurology

Maas AIR, Menon DK, Manley GT

Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury.

Translational psychiatry

Stein MB, Jain S, Parodi L, Choi KW, Maihofer AX, Nelson LD, Mukherjee P, Sun X, He F, Okonkwo DO, Giacino JT, Korley FK, Vassar MJ, Robertson CS, McCrea MA, Temkin N, Markowitz AJ, Diaz-Arrastia R, Rosand J, Manley GT, TRACK-TBI Investigators

On-Call Junior Neurosurgery Residents Spend 9 hours of Their On-Call Shift Actively Using the Electronic Health Record.

Neurosurgery

Patel A, Mummaneni PV, Zheng J, Rosner BI, Thombley R, Sorour O, Theodosopoulos PV, Aghi MK, Berger MS, Chang EF, Chou D, Manley GT, DiGiorgio AM

Correction to: Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Kulbe JR, Jain S, Nelson LD, Korley FK, Mukherjee P, Sun X, Okonkwo DO, Giacino JT, Vassar MJ, Robertson CS, McCrea MA, Wang KKW, Temkin N, Mac Donald CL, Taylor SR, Ferguson AR, Markowitz AJ, Diaz-Arrastia R, Manley GT, Stein MB, TRACK-TBI Investigators

Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study.

Brain communications

Gardner RC, Puccio AM, Korley FK, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Puffer RC, Yuh EL, Yue JK, Sun X, Taylor SR, Mukherjee P, Jain S, Manley GT, TRACK-TBI Investigators

Feasibility and Utility of a Flexible Outcome Assessment Battery for Longitudinal Traumatic Brain Injury Research: A TRACK-TBI Study.

Journal of neurotrauma

Bodien YG, Barber J, Taylor SR, Boase K, Corrigan JD, Dikmen S, Gardner RC, Kramer JH, Levin H, Machamer J, McAllister T, Nelson LD, Ngwenya LB, Sherer M, Stein MB, Vassar M, Whyte J, Yue JK, Markowitz A, McCrea MA, Manley GT, Temkin N, Giacino JT

Traumatic brain injury: progress and challenges in prevention, clinical care, and research.

The Lancet. Neurology

Maas AIR, Menon DK, Manley GT, Abrams M, ?kerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, B?ki A, Chesnut RM, Citerio G, Clark D, Clasby B, Cooper DJ, Czeiter E, Czosnyka M, Dams-O'Connor K, De Keyser V, Diaz-Arrastia R, Ercole A, van Essen TA, Falvey ?, Ferguson AR, Figaji A, Fitzgerald M, Foreman B, Gantner D, Gao G, Giacino J, Gravesteijn B, Guiza F, Gupta D, Gurnell M, Haagsma JA, Hammond FM, Hawryluk G, Hutchinson P, van der Jagt M, Jain S, Jain S, Jiang JY, Kent H, Kolias A, Kompanje EJO, Lecky F, Lingsma HF, Maegele M, Majdan M, Markowitz A, McCrea M, Meyfroidt G, Mikolic A, Mondello S, Mukherjee P, Nelson D, Nelson LD, Newcombe V, Okonkwo D, Ore?ic M, Peul W, Pisica D, Polinder S, Ponsford J, Puybasset L, Raj R, Robba C, R?e C, Rosand J, Schueler P, Sharp DJ, Smielewski P, Stein MB, von Steinb?chel N, Stewart W, Steyerberg EW, Stocchetti N, Temkin N, Tenovuo O, Theadom A, Thomas I, Espin AT, Turgeon AF, Unterberg A, Van Praag D, van Veen E, Verheyden J, Vyvere TV, Wang KKW, Wiegers EJA, Williams WH, Wilson L, Wisniewski SR, Younsi A, Yue JK, Yuh EL, Zeiler FA, Zeldovich M, Zemek R, InTBIR Participants and Investigators

Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Cai LT, Brett BL, Palacios EM, Yuh EL, Bourla I, Wren-Jarvis J, Wang Y, Mac Donald C, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Levin HS, Robertson CS, Temkin N, Markowitz AJ, Manley GT, Stein MB, McCrea MA, Zafonte RD, Nelson LD, Mukherjee P, TRACK-TBI Investigators

Predictors of Extreme Hospital Length of Stay After Traumatic Brain Injury.

World neurosurgery

Yue JK, Krishnan N, Chyall L, Haddad AF, Vega P, Caldwell DJ, Umbach G, Tantry E, Tarapore PE, Huang MC, Manley GT, DiGiorgio AM

Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study.

The Lancet. Neurology

Korley FK, Jain S, Sun X, Puccio AM, Yue JK, Gardner RC, Wang KKW, Okonkwo DO, Yuh EL, Mukherjee P, Nelson LD, Taylor SR, Markowitz AJ, Diaz-Arrastia R, Manley GT, TRACK-TBI Study Investigators

Traumatic brain injury over the past 20 years: research and clinical progress.

The Lancet. Neurology

Maas AIR, Fitzgerald M, Gao G, Gupta D, Hutchinson P, Manley GT, Menon DK

Developing a National Trauma Research Action Plan: Results from the long-term outcomes research gap Delphi survey.

The journal of trauma and acute care surgery

Herrera-Escobar JP, Reidy E, Phuong J, Brasel KJ, Cuschieri J, Fallat M, Potter BK, Price MA, Bulger EM, Haider AH, Bonne S, Brasel KJ, Cuschieri J, de Roon-Cassini T, Dicker RA, Fallat M, Ficke JR, Gabbe B, Gibran NS, Heinemann AW, Ho V, Kao LS, Kellam JF, Kurowski BG, Levy-Carrick NC, Livingston D, Mandell SP, Manley GT, Michetti CP, Miller AN, Newcomb A, Okonkwo D, Potter BK, Seamon M, Stein D, Wagner AK, Whyte J, Yonclas P, Zatzick D, Zielinski MD, NTRAP Long-term Outcomes Panel

Outcomes in Patients With Mild Traumatic Brain Injury Without Acute Intracranial Traumatic Injury.

JAMA network open

Madhok DY, Rodriguez RM, Barber J, Temkin NR, Markowitz AJ, Kreitzer N, Manley GT, TRACK-TBI Investigators

Risk factors for high symptom burden 3 months after traumatic brain injury and implications for clinical trial design: a TRACK-TBI study.

Journal of neurotrauma

Temkin N, Machamer J, Dikmen S, Nelson LD, Barber J, Hwang P, Boase K, Stein MB, Sun X, Giacino J, McCrea M, Taylor S, Jain S, Manley GT

Diffusion Tensor Imaging Reveals Elevated Diffusivity of White Matter Microstructure that is Independently Associated with Long-Term Outcome after Mild Traumatic Brain Injury: A TRACK-TBI Study.

Journal of neurotrauma

Palacios EM, Yuh EL, Mac Donald CL, Bourla I, Wren-Jarvis J, Sun X, Vassar M, Diaz-Arrastia RR, Giacino J, Okonkwo DO, Robertson CS, Stein MB, Temkin N, McCrea M, Levin H, Markowitz A, Jain S, Manley GT, Mukherjee P

Evacuation of a multi-loculated acute-on-chronic subdural hematoma using tandem bedside subdural evacuation port systems.

Trauma case reports

Yue JK, Haddad AF, Wang AS, Caldwell DJ, Umbach G, Digiorgio AM, Tarapore PE, Huang MC, Manley GT

Association of day-of-injury serum glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Kulbe JR, Jain S, Nelson LD, Korley FK, Mukherjee P, Sun X, Okonkwo DO, Giacino JT, Vassar MJ, Robertson CS, McCrea MA, Wang KKW, Temkin N, Mac Donald CL, Taylor SR, Ferguson AR, Markowitz AJ, Diaz-Arrastia R, Manley GT, Stein MB, TRACK-TBI Investigators

Employment and Economic Outcomes of Participants With Mild Traumatic Brain Injury in the TRACK-TBI Study.

JAMA network open

Gaudette É, Seabury SA, Temkin N, Barber J, DiGiorgio AM, Markowitz AJ, Manley GT, TRACK-TBI Investigators

Improving the Precision of the Glasgow Outcome Scale-Extended Using Item Response Theory: A TRACK-TBI Study.

Journal of neurotrauma

Magnus BE, Balsis S, Giacino J, McCrea M, Temkin N, Whyte J, Manley GT, Nelson LD

Is the Centers for Medicare and Medicaid Services Hierarchical Condition Category Risk Adjustment Model Satisfactory for Quantifying Risk After Spine Surgery?

Neurosurgery

Chan AK, Shahrestani S, Ballatori AM, Orrico KO, Manley GT, Tarapore PE, Huang M, Dhall SS, Chou D, Mummaneni PV, DiGiorgio AM

The Case for Optimized Edge-Centric Tractography at Scale.

Frontiers in neuroinformatics

Moon JY, Mukherjee P, Madduri RK, Markowitz AJ, Cai LT, Palacios EM, Manley GT, Bremer PT

Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.

PloS one

Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone WD, Ferguson AR, TRACK-SCI Investigators

Empowering Data Sharing and Analytics through the Open Data Commons for Traumatic Brain Injury Research.

Neurotrauma reports

Chou A, Torres-Espín A, Huie JR, Krukowski K, Lee S, Nolan A, Guglielmetti C, Hawkins BE, Chaumeil MM, Manley GT, Beattie MS, Bresnahan JC, Martone ME, Grethe JS, Rosi S, Ferguson AR

Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury.

Neurosurgical focus

Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone WD, Bresnahan JC, Manley GT, Beattie MS, DiGiorgio AM

A genome-wide association study of outcome from traumatic brain injury.

EBioMedicine

Kals M, Kunzmann K, Parodi L, Radmanesh F, Wilson L, Izzy S, Anderson CD, Puccio AM, Okonkwo DO, Temkin N, Steyerberg EW, Stein MB, Manley GT, Maas AIR, Richardson S, Diaz-Arrastia R, Palotie A, Ripatti S, Rosand J, Menon DK, Genetic Associations In Neurotrauma (GAIN) Consortium (with contribution from the CENTER-TBI, TRACK-

Mixture Model Framework for Traumatic Brain Injury Prognosis Using Heterogeneous Clinical and Outcome Data.

IEEE journal of biomedical and health informatics

Kaplan AD, Cheng Q, Mohan KA, Nelson LD, Jain S, Levin H, Torres-Espin A, Chou A, Huie JR, Ferguson AR, Mccrea M, Giacino J, Sundaram S, Markowitz AJ, Manley GT

How Do Scores on the Functional Status Examination (FSE) Correspond to Scores on the Glasgow Outcome Scale-Extended (GOSE)?

Neurotrauma reports

Nelson LD, Magnus BE, Temkin NR, Dikmen S, Manley GT, Balsis S

Cognitive Outcome 1 Year After Mild Traumatic Brain Injury: Results From the TRACK-TBI Study.

Neurology

Christman Schneider AL, Huie JR, Boscardin WJ, Nelson L, Barber JK, Yaffe K, Diaz-Arrastia R, Ferguson AR, Kramer J, Jain S, Temkin N, Yuh E, Manley GT, Gardner RC, TRACK-TBI Investigators

Blood GFAP as an emerging biomarker in brain and spinal cord disorders.

Nature reviews. Neurology

Abdelhak A, Foschi M, Abu-Rumeileh S, Yue JK, D'Anna L, Huss A, Oeckl P, Ludolph AC, Kuhle J, Petzold A, Manley GT, Green AJ, Otto M, Tumani H

Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation.

The Lancet. Neurology

Galimberti S, Graziano F, Maas AIR, Isernia G, Lecky F, Jain S, Sun X, Gardner RC, Taylor SR, Markowitz AJ, Manley GT, Valsecchi MG, Bellelli G, Citerio G, CENTER-TBI and TRACK-TBI participants and investigators

Do social determinants of health impact access to neurosurgical care in the United States? A workforce perspective.

Journal of neurosurgery

Perera S, Hervey-Jumper SL, Mummaneni PV, Barthélemy EJ, Haddad AF, Marotta DA, Burke JF, Chan AK, Manley GT, Tarapore PE, Huang MC, Dhall SS, Chou D, Orrico KO, DiGiorgio AM

Developing a National Trauma Research Action Plan (NTRAP): Results from the Neurotrauma Research Panel Delphi Survey.

The journal of trauma and acute care surgery

Stein DM, Braverman MA, Phuong J, Shipper E, Price MA, Bixby PJ, Adelson PD, Ansel BM, Cifu DX, DeVine JG, Galvagno SM, Gelb DE, Harris O, Kang CS, Kitagawa RS, McQuillan KA, Patel MB, Robertson CS, Salim A, Shutter L, Valadka AB, Bulger EM, Adelson PD, Ansel BM, Chesnut RM, Cifu DX, DeVine JG, Galvagno SM, Gelb DE, Giacino JT, Harris O, Hawryluk G, Kang CS, Kitagawa RS, Manley GT, McQuillan KA, Merck LH, Okonkwo DO, Patel MB, Robertson CS, Salim A, Shackelford CSA, Sheth KN, Shutter L, Stein DM, Valadka AB, Wade CE, Whyte J, And the NTRAP Neurotrauma Panel Group

Trajectories of Insomnia in Adults After Traumatic Brain Injury.

JAMA network open

Wickwire EM, Albrecht JS, Capaldi VF, Jain SO, Gardner RC, Werner JK, Mukherjee P, McKeon AB, Smith MT, Giacino JT, Nelson LD, Williams SG, Collen J, Sun X, Schnyer DM, Markowitz AJ, Manley GT, Krystal AD, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators

Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury.

JAMA network open

Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R, TRACK-TBI Investigators, Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R

Correction to: Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study.

Neurocritical care

Williams JR, Nieblas-Bedolla E, Feroze A, Young C, Temkin NR, Giacino JT, Okonkwo DO, Manley GT, Barber J, Durfy S, Markowitz AJ, Yuh EL, Mukherjee P, Mac Donald CL, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators

Diagnosing Level of Consciousness: The Limits of the Glasgow Coma Scale Total Score.

Journal of neurotrauma

Bodien Y, Barra A, Temkin N, Barber J, Foreman B, Vassar M, Robertson CS, Taylor SR, Markowitz AJ, Manley GT, Giacino J, Edlow BL

The Morbidity and Mortality of Surgery for Traumatic Brain Injury in Geriatric Patients: A Study of Over 100 000 Patient Cases.

Neurosurgery

Haddad AF, DiGiorgio AM, Lee YM, Lee AT, Burke JF, Huang MC, Dhall SS, Manley GT, Tarapore PE

Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury.

eLife

Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, Whetstone WD, Bresnahan JC, Beattie MS, McKenna SL, Pan JZ, Ferguson AR, TRACK-SCI Investigators

FAIR Data Reuse in Traumatic Brain Injury: Exploring Inflammation and Age as Moderators of Recovery in the TRACK-TBI Pilot.

Frontiers in neurology

Huie JR, Chou A, Torres-Espin A, Nielson JL, Yuh EL, Gardner RC, Diaz-Arrastia R, Manley GT, Ferguson AR, TRACK-TBI Investigators

Association Between TBI-Related Hearing Impairment and Cognition: A TRACK-TBI Study.

The Journal of head trauma rehabilitation

Hwang PH, Nelson LD, Sharon JD, McCrea MA, Dikmen SS, Markowitz AJ, Manley GT, Temkin NR, TRACK-TBI Investigators

Comparing the Quality of Life After Brain Injury-Overall Scale (QOLIBRI-OS) and Satisfaction with Life Scale (SWLS) as Outcome Measures for Traumatic Brain Injury Research.

Journal of neurotrauma

Kreitzer NP, Jain S, Young J, Sun X, Stein MB, McCrea M, Levin H, Giacino J, Markowitz AJ, Manley GT, Nelson LD

Interrater Reliability of NIH TBI Imaging Common Data Elements for Brain MRI in Mild TBI.

Journal of neurotrauma

Rincon SP, Mukherjee P, Levin H, Temkin N, Mac Donald CL, Krainak DM, Sun X, Jain S, Taylor SR, Markowitz A, Kumar A, Manley GT, Yuh EL

Depression in Older Adults 12 Months Following Traumatic Brain Injury: A TRACK-TBI Study.

Archives of physical medicine and rehabilitation

Passler JS, Sander A, Temkin NR, Barber J, Gardner RC, TRACK-TBI Investigators*

Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI.

JAMA neurology

Yuh EL, Jain S, Sun X, Pisica D, Harris MH, Taylor SR, Markowitz AJ, Mukherjee P, Verheyden J, Giacino JT, Levin HS, McCrea M, Stein MB, Temkin NR, Diaz-Arrastia R, Robertson CS, Lingsma HF, Okonkwo DO, Maas AIR, Manley GT, TRACK-TBI Investigators for the CENTER-TBI Investigators
, Adeoye O, Badjatia N, Boase K, Bodien Y, Corrigan JD, Crawford K, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Keene CD, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Nelson L, Ngwenya LB, Noel F, Nolan A, Palacios E, Perl D, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Toga A, Valadka A, Vassar M, Zafonte R

Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study.

JAMA neurology

McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS, Dikmen S, Stein M, Bodien YG, Boase K, Taylor SR, Vassar M, Mukherjee P, Robertson C, Diaz-Arrastia R, Okonkwo DO, Markowitz AJ, Manley GT, TRACK-TBI Investigators , Adeoye O, Badjatia N, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Goldman D, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Keene CD, Korley FK, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Ngwenya LB, Noel F, Nolan A, Palacios E, Perl D, Puccio A, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Toga A, Valadka A, Wang K, Yue JK, Yuh E, Zafonte R

Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study.

Neurocritical care

Williams JR, Nieblas-Bedolla E, Feroze A, Young C, Temkin NR, Giacino JT, Okonkwo DO, Manley GT, Barber J, Durfy S, Markowitz AJ, Yu EL, Mukherjee P, Mac Donald CL, and The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investiga

Relationship between transdiagnostic dimensions of psychopathology and traumatic brain injury (TBI): A TRACK-TBI study.

Journal of abnormal psychology

Nelson LD, Kramer MD, Joyner KJ, Patrick CJ, Stein MB, Temkin N, Levin HS, Whyte J, Markowitz AJ, Giacino J, Manley GT, TRACK-TBI Investigators

Comparison of GFAP and UCH-L1 Measurements from Two Prototype Assays: The Abbott i-STAT and ARCHITECT Assays.

Neurotrauma reports

Korley FK, Datwyler SA, Jain S, Sun X, Beligere G, Chandran R, Marino JA, McQuiston B, Zhang H, Caudle KL, Wang KKW, Puccio AM, Okonkwo DO, Yue JK, Taylor SR, Markowitz A, Manley GT, Diaz-Arrastia R

A Manual for the Glasgow Outcome Scale-Extended (GOSE) Interview.

Journal of neurotrauma

Wilson L, Boase K, Nelson LD, Temkin N, Giacino JT, Markowitz AJ, Maas A, Menon D, Teasdale GM, Manley GT

Predictors of six-month inability to return to work in previously employed subjects after mild traumatic brain injury: A TRACK-TBI pilot study.

Journal of concussion

Yue JK, Phelps RR, Hemmerle DD, Upadhyayula PS, Winkler EA, Deng H, Chang D, Vassar MJ, Taylor SR, Schnyer DM, Lingsma HF, Puccio AM, Yuh EL, Mukherjee P, Huang MC, Ngwenya LB, Valadka AB, Markowitz AJ, Okonkwo DO, Manley GT, TRACK-TBI Investigators

Association of Sex and Age With Mild Traumatic Brain Injury-Related Symptoms: A TRACK-TBI Study.

JAMA network open

Levin HS, Temkin NR, Barber J, Nelson LD, Robertson C, Brennan J, Stein MB, Yue JK, Giacino JT, McCrea MA, Diaz-Arrastia R, Mukherjee P, Okonkwo DO, Boase K, Markowitz AJ, Bodien Y, Taylor S, Vassar MJ, Manley GT, TRACK-TBI Investigators , Adeoye O, Badjatia N, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Keene CD, Korley FK, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Nolan A, Ngwenya LB, Noel F, Palacios E, Puccio A, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sun X, Toga A, Valadka A, Wang K, Yuh E, Zafonte R

Letter to the Editor. Discrepancies in national databases for TBI estimates.

Journal of neurosurgery

Madhok DY, Hsia RY, Manley GT

Diagnostic blood RNA profiles for human acute spinal cord injury.

The Journal of experimental medicine

Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein PR, Manley GT, Dhall SS, Ferguson AR, Oldham MC, Bresnahan JC, Beattie MS

Latent Profile Analysis of Neuropsychiatric Symptoms and Cognitive Function of Adults 2 Weeks After Traumatic Brain Injury: Findings From the TRACK-TBI Study.

JAMA network open

Brett BL, Kramer MD, Whyte J, McCrea MA, Stein MB, Giacino JT, Sherer M, Markowitz AJ, Manley GT, Nelson LD, TRACK-TBI Investigators , Adeoye O, Badjatia N, Boase K, Barber J, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Keene CD, Korley FK, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Mukherjee P, Ngwenya LB, Noel F, Okonkwo D, Palacios E, Puccio A, Rabinowitz M, Robertson C, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Taylor S, Temkin N, Toga A, Valadka A, Vassar M, Wang K, Yue JK, Yuh E, Zafonte R

Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study.

Journal of neurotrauma

Nolan AL, Petersen C, Iacono D, Mac Donald CL, Mukherjee P, van der Kouwe A, Jain S, Stevens A, Diamond B, Wang R, Markowitz AJ, Fischl B, Perl D, Manley GT, Keene CD, Diaz-Arrastia R, Edlow BL

Risk Factors for Suicidal Ideation Following Mild Traumatic Brain Injury: A TRACK-TBI Study.

The Journal of head trauma rehabilitation

Campbell-Sills L, Jain S, Sun X, Fisher LB, Agtarap SD, Dikmen S, Nelson LD, Temkin N, McCrea M, Yuh E, Giacino JT, Manley GT, Stein MB

High-Sensitivity C-Reactive Protein Is a Prognostic Biomarker of Six-Month Disability after Traumatic Brain Injury: Results from the TRACK-TBI Study.

Journal of neurotrauma

Xu LB, Yue JK, Korley F, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Puffer RC, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Manley GT, Diaz-Arrastia R

An evidence-based methodology for systematic evaluation of clinical outcome assessment measures for traumatic brain injury.

PloS one

Christoforou AN, Armstrong MJ, Bergin MJG, Robbins A, Merillat SA, Erwin P, Getchius TSD, McCrea M, Markowitz AJ, Manley GT, Giacino JT

Satisfaction with Life after Mild Traumatic Brain Injury: A TRACK-TBI Study.

Journal of neurotrauma

Agtarap SD, Campbell-Sills L, Jain S, Sun X, Dikmen S, Levin H, McCrea MA, Mukherjee P, Nelson LD, Temkin N, Yuh EL, Giacino JT, Manley GT, Stein MB

Validity of the Brief Test of Adult Cognition by Telephone in Level 1 Trauma Center Patients Six Months Post-Traumatic Brain Injury: A TRACK-TBI Study.

Journal of neurotrauma

Nelson LD, Barber JK, Temkin NR, Dams-O'Connor K, Dikmen S, Giacino JT, Kramer MD, Levin HS, McCrea MA, Whyte J, Bodien YG, Yue JK, Manley GT

Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Cohen-Adad J, Dhall SS, Talbott JF

Does state malpractice environment affect outcomes following spinal fusions? A robust statistical and machine learning analysis of 549,775 discharges following spinal fusion surgery in the United States.

Neurosurgical focus

Chan AK, Santacatterina M, Pennicooke B, Shahrestani S, Ballatori AM, Orrico KO, Burke JF, Manley GT, Tarapore PE, Huang MC, Dhall SS, Chou D, Mummaneni PV, DiGiorgio AM

Smaller Regional Brain Volumes Predict Posttraumatic Stress Disorder at 3 Months After Mild Traumatic Brain Injury.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Stein MB, Yuh E, Jain S, Okonkwo DO, Mac Donald CL, Levin H, Giacino JT, Dikmen S, Vassar MJ, Diaz-Arrastia R, Robertson CS, Nelson LD, McCrea M, Sun X, Temkin N, Taylor SR, Markowitz AJ, Manley GT, Mukherjee P

Point-of-Care Platform Blood Biomarker Testing of Glial Fibrillary Acidic Protein versus S100 Calcium-Binding Protein B for Prediction of Traumatic Brain Injuries: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.

Journal of neurotrauma

Okonkwo DO, Puffer RC, Puccio AM, Yuh EL, Yue JK, Diaz-Arrastia R, Korley FK, Wang KKW, Sun X, Taylor SR, Mukherjee P, Markowitz AJ, Jain S, Manley GT

Analysis of Normal High-Frequency Intracranial Pressure Values and Treatment Threshold in Neurocritical Care Patients: Insights into Normal Values and a Potential Treatment Threshold.

JAMA neurology

Hawryluk GWJ, Nielson JL, Huie JR, Zimmermann L, Saigal R, Ding Q, Hirschi R, Zeiler FA, Ferguson AR, Manley GT

Sideline Concussion Assessment: The Current State of the Art.

Neurosurgery

Yue JK, Phelps RRL, Chandra A, Winkler EA, Manley GT, Berger MS

The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study.

Science advances

Palacios EM, Owen JP, Yuh EL, Wang MB, Vassar MJ, Ferguson AR, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Robertson CS, Stein MB, Temkin N, Jain S, McCrea M, MacDonald CL, Levin HS, Manley GT, Mukherjee P

Polytrauma Is Associated with Increased Three- and Six-Month Disability after Traumatic Brain Injury: A TRACK-TBI Pilot Study.

Neurotrauma reports

Yue JK, Satris GG, Dalle Ore CL, Huie JR, Deng H, Winkler EA, Lee YM, Vassar MJ, Taylor SR, Schnyer DM, Lingsma HF, Puccio AM, Yuh EL, Mukherjee P, Valadka AB, Ferguson AR, Markowitz AJ, Okonkwo DO, Manley GT

Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.

Neurosurgical focus

Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Haefeli J, Weinstein PR, de Almeida Neto CA, Kuo YH, Taggard D, Talbott JF, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Dhall SS

Substance use on admission toxicology screen is associated with peri-injury factors and six-month outcome after traumatic brain injury: A TRACK-TBI Pilot study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Yue JK, Phelps RRL, Winkler EA, Deng H, Upadhyayula PS, Vassar MJ, Madhok DY, Schnyer DM, Puccio AM, Lingsma HF, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT

Common Data Elements: Critical Assessment of Harmonization between Current Multi-Center Traumatic Brain Injury Studies.

Journal of neurotrauma

Meeuws S, Yue JK, Huijben JA, Nair N, Lingsma HF, Bell MJ, Manley GT, Maas AIR

Revisits, readmissions, and outcomes for pediatric traumatic brain injury in California, 2005-2014.

PloS one

Hsia RY, Mannix RC, Guo J, Kornblith AE, Lin F, Sokolove PE, Manley GT

Suppression tuning of spontaneous otoacoustic emissions in the barn owl (Tyto alba).

Hearing research

Engler S, Köppl C, Manley GA, de Kleine E, van Dijk P

The Functional Status Examination in Mild Traumatic Brain Injury: A TRACK-TBI Sub-Study.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Zahniser E, Temkin NR, Machamer J, Barber J, Manley GT, Markowitz AJ, Dikmen SS

Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study.

World neurosurgery

Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, Mummaneni PV, Dhall SS

Pediatric firearm-related traumatic brain injury in United States trauma centers.

Journal of neurosurgery. Pediatrics

Deng H, Yue JK, Winkler EA, Dhall SS, Manley GT, Tarapore PE

Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study.

JAMA neurology

Nelson LD, Temkin NR, Dikmen S, Barber J, Giacino JT, Yuh E, Levin HS, McCrea MA, Stein MB, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson A, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Korley F, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Noel F, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson CS, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Taylor S, Toga A, Valadka A, Vassar MJ, Vespa P, Wang K, Yue JK, Zafonte R

The LONI QC System: A Semi-Automated, Web-Based and Freely-Available Environment for the Comprehensive Quality Control of Neuroimaging Data.

Frontiers in neuroinformatics

Kim H, Irimia A, Hobel SM, Pogosyan M, Tang H, Petrosyan P, Blanco REC, Duffy BA, Zhao L, Crawford KL, Liew SL, Clark K, Law M, Mukherjee P, Manley GT, Van Horn JD, Toga AW

Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study.

The Lancet. Neurology

Yue JK, Yuh EL, Korley FK, Winkler EA, Sun X, Puffer RC, Deng H, Choy W, Chandra A, Taylor SR, Ferguson AR, Huie JR, Rabinowitz M, Puccio AM, Mukherjee P, Vassar MJ, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Jain S, Manley GT

In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.

Neurosurgery

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS

Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.

Neurosurgery

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS

Sleep disturbances precede depressive symptomatology following traumatic brain injury.

Current neurobiology

Wickwire EM, Albrecht JS, Griffin NR, Schnyer DM, Yue JK, Markowitz AJ, Okonkwo DO, Valadka AB, Badjatia N, Manley GT, TRACK-TBI Investigators

Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury : Consensus statement.

Acta neurochirurgica

Hutchinson PJ, Kolias AG, Tajsic T, Adeleye A, Aklilu AT, Apriawan T, Bajamal AH, Barthélemy EJ, Devi BI, Bhat D, Bulters D, Chesnut R, Citerio G, Cooper DJ, Czosnyka M, Edem I, El-Ghandour NMF, Figaji A, Fountas KN, Gallagher C, Hawryluk GWJ, Iaccarino C, Joseph M, Khan T, Laeke T, Levchenko O, Liu B, Liu W, Maas A, Manley GT, Manson P, Mazzeo AT, Menon DK, Michael DB, Muehlschlegel S, Okonkwo DO, Park KB, Rosenfeld JV, Rosseau G, Rubiano AM, Shabani HK, Stocchetti N, Timmons SD, Timofeev I, Uff C, Ullman JS, Valadka A, Waran V, Wells A, Wilson MH, Servadei F

Diagnosing the GOSE: Structural and Psychometric Properties Using Item Response Theory, a TRACK-TBI Pilot Study.

Journal of neurotrauma

Ranson J, Magnus BE, Temkin N, Dikmen S, Giacino JT, Okonkwo DO, Valadka AB, Manley GT, Nelson LD

A Comparison of Satisfaction With Life and the Glasgow Outcome Scale-Extended After Traumatic Brain Injury: An Analysis of the TRACK-TBI Pilot Study.

The Journal of head trauma rehabilitation

Kreitzer NP, Hart K, Lindsell CJ, Manley GT, Dikmen SS, Ratcliff JJ, Yue JK, Adeoye OM

The Effect of Goal-Directed Therapy on Patient Morbidity and Mortality After Traumatic Brain Injury: Results From the Progesterone for the Treatment of Traumatic Brain Injury III Clinical Trial.

Critical care medicine

Merck LH, Yeatts SD, Silbergleit R, Manley GT, Pauls Q, Palesch Y, Conwit R, Le Roux P, Miller J, Frankel M, Wright DW

Age and sex-mediated differences in six-month outcomes after mild traumatic brain injury in young adults: a TRACK-TBI study.

Neurological research

Yue JK, Levin HS, Suen CG, Morrissey MR, Runyon SJ, Winkler EA, Puffer RC, Deng H, Robinson CK, Rick JW, Phelps RRL, Sharma S, Taylor SR, Vassar MJ, Cnossen MC, Lingsma HF, Gardner RC, Temkin NR, Barber J, Dikmen SS, Yuh EL, Mukherjee P, Stein MB, Cage TA, Valadka AB, Okonkwo DO, Manley GT

Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3- and 6-Months After Mild Traumatic Brain Injury: A TRACK-TBI Study.

Frontiers in neurology

Yue JK, Cnossen MC, Winkler EA, Deng H, Phelps RRL, Coss NA, Sharma S, Robinson CK, Suen CG, Vassar MJ, Schnyer DM, Puccio AM, Gardner RC, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Lingsma HF, Manley GT

Characterizing the Response to Cerebrospinal Fluid Drainage in Patients with an External Ventricular Drain: The Pressure Equalization Ratio.

Neurocritical care

Candanedo C, Doron O, Hemphill JC, Ramirez de Noriega F, Manley GT, Patal R, Rosenthal G

Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study.

JAMA psychiatry

Stein MB, Jain S, Giacino JT, Levin H, Dikmen S, Nelson LD, Vassar MJ, Okonkwo DO, Diaz-Arrastia R, Robertson CS, Mukherjee P, McCrea M, Mac Donald CL, Yue JK, Yuh E, Sun X, Campbell-Sills L, Temkin N, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson A, Foreman B, Gardner R, Gaudette E, Giacino JT, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, McCrea M, Merchant R, Mukherjee P, Nelson LD, Noel F, Okonkwo DO, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson CS, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Stein MB, Taylor S, Toga A, Temkin N, Valadka A, Vassar MJ, Vespa P, Wang K, Yue JK, Yuh E, Zafonte R

The Temporal Relationship of Mental Health Problems and Functional Limitations following mTBI: A TRACK-TBI and TED Study.

Journal of neurotrauma

Zahniser E, Nelson LD, Dikmen SS, Machamer JE, Stein MB, Yuh E, Manley GT, Temkin NR

Rehabilitation Trajectories and Outcomes in Individuals With Mild Traumatic Brain Injury and Psychiatric Histories: A TRACK-TBI Pilot Study.

The Journal of head trauma rehabilitation

Bertisch H, Satris G, Temkin N, Barber J, Manley GT

A swine model of intracellular cerebral edema - Cerebral physiology and intracranial compliance.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Ramirez de Noriega F, Manley GT, Moscovici S, Itshayek E, Tamir I, Fellig Y, Shkara RA, Rosenthal G

Testing a Multivariate Proteomic Panel for Traumatic Brain Injury Biomarker Discovery: A TRACK-TBI Pilot Study.

Journal of neurotrauma

Huie JR, Diaz-Arrastia R, Yue JK, Sorani MD, Puccio AM, Okonkwo DO, Manley GT, Ferguson AR

Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: a TRACK-TBI study.

Neurological research

Yue JK, Winkler EA, Puffer RC, Deng H, Phelps RRL, Wagle S, Morrissey MR, Rivera EJ, Runyon SJ, Vassar MJ, Taylor SR, Cnossen MC, Lingsma HF, Yuh EL, Mukherjee P, Schnyer DM, Puccio AM, Valadka AB, Okonkwo DO, Manley GT

Adult Firearm-Related Traumatic Brain Injury in United States Trauma Centers.

Journal of neurotrauma

Deng H, Yue JK, Winkler EA, Dhall SS, Manley GT, Tarapore PE

Sleep, Sleep Disorders, and Circadian Health following Mild Traumatic Brain Injury in Adults: Review and Research Agenda.

Journal of neurotrauma

Wickwire EM, Schnyer DM, Germain A, Williams SG, Lettieri CJ, McKeon AB, Scharf SM, Stocker R, Albrecht J, Badjatia N, Markowitz AJ, Manley GT

Travelling waves and tonotopicity in the inner ear: a historical and comparative perspective.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology

Manley GA

Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant Traumatic Brain Injury Biomarkers.

Journal of neurotrauma

Korley FK, Yue JK, Wilson DH, Hrusovsky K, Diaz-Arrastia R, Ferguson AR, Yuh EL, Mukherjee P, Wang KKW, Valadka AB, Puccio AM, Okonkwo DO, Manley GT

Prediction of Persistent Post-Concussion Symptoms after Mild Traumatic Brain Injury.

Journal of neurotrauma

Cnossen MC, van der Naalt J, Spikman JM, Nieboer D, Yue JK, Winkler EA, Manley GT, von Steinbuechel N, Polinder S, Steyerberg EW, Lingsma HF

Sub-classifying patients with mild traumatic brain injury: A clustering approach based on baseline clinical characteristics and 90-day and 180-day outcomes.

PloS one

Si B, Dumkrieger G, Wu T, Zafonte R, Valadka AB, Okonkwo DO, Manley GT, Wang L, Dodick DW, Schwedt TJ, Li J

Age-Related Differences in Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein and Tau for Identifying Acute Intracranial Trauma on Computed Tomography: A TRACK-TBI Study.

Journal of neurotrauma

Gardner RC, Rubenstein R, Wang KKW, Korley FK, Yue JK, Yuh EL, Mukherje P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT

Predictors of 30-Day Outcomes in Octogenarians with Traumatic C2 Fractures Undergoing Surgery.

World neurosurgery

Yue JK, Ordaz A, Winkler EA, Deng H, Suen CG, Burke JF, Chan AK, Manley GT, Dhall SS, Tarapore PE

Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study.

Brain injury

Ngwenya LB, Gardner RC, Yue JK, Burke JF, Ferguson AR, Huang MC, Winkler EA, Pirracchio R, Satris GG, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT

Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury.

Neurosurgery

Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD

Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion: Results From the TRACK-TBI Study.

JAMA network open

Seabury SA, Gaudette É, Goldman DP, Markowitz AJ, Brooks J, McCrea MA, Okonkwo DO, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson A, Foreman B, Gardner R, Giacino J, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Mukherjee P, Nelson L, Noel F, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson C, Rosand J, Sander A, Satris G, Schnyer D, Sherer M, Stein M, Taylor S, Temkin N, Toga A, Valadka A, Vassar M, Vespa P, Wang K, Yue J, Yuh E, Zafonte R

Optimizing Outcome Assessment in Multicenter TBI Trials: Perspectives From TRACK-TBI and the TBI Endpoints Development Initiative.

The Journal of head trauma rehabilitation

Bodien YG, McCrea M, Dikmen S, Temkin N, Boase K, Machamer J, Taylor SR, Sherer M, Levin H, Kramer JH, Corrigan JD, McAllister TW, Whyte J, Manley GT, Giacino JT

Functional Status Examination in Patients with Moderate-to-Severe Traumatic Brain Injuries.

Journal of neurotrauma

Machamer J, Temkin NR, Manley GT, Dikmen S

Spontaneous otoacoustic emissions in teiid lizards.

Hearing research

Manley GA, Wartini A, Schwabedissen G, Siegl E

Cerebral blood vessel damage in traumatic brain injury.

Clinical biomechanics (Bristol, Avon)

Monson KL, Converse MI, Manley GT

Geriatric Traumatic Brain Injury: Epidemiology, Outcomes, Knowledge Gaps, and Future Directions.

Journal of neurotrauma

Gardner RC, Dams-O'Connor K, Morrissey MR, Manley GT

The Berlin International Consensus Meeting on Concussion in Sport.

Neurosurgery

Davis GA, Ellenbogen RG, Bailes J, Cantu RC, Johnston KM, Manley GT, Nagahiro S, Sills A, Tator CH, McCrory P

An update on diagnostic and prognostic biomarkers for traumatic brain injury.

Expert review of molecular diagnostics

Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley GT

Preinjury employment status as a risk factor for symptomatology and disability in mild traumatic brain injury: A TRACK-TBI analysis.

NeuroRehabilitation

Yue JK, Rick JW, Morrissey MR, Taylor SR, Deng H, Suen CG, Vassar MJ, Cnossen MC, Lingsma HF, Yuh EL, Mukherjee P, Gardner RC, Valadka AB, Okonkwo DO, Cage TA, Manley GT

Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data.

Neurosurgical focus

DiGiorgio AM, Tsolinas R, Alazzeh M, Haefeli J, Talbott JF, Ferguson AR, Bresnahan JC, Beattie MS, Manley GT, Whetstone WD, Mummaneni PV, Dhall SS

The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis.

Brain injury

Shahjouei S, Sadeghi-Naini M, Yang Z, Kobeissy F, Rathore D, Shokraneh F, Blackburn S, Manley GT, Wang KKW

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers.

JAMA neurology

Rubenstein R, Chang B, Yue JK, Chiu A, Winkler EA, Puccio AM, Diaz-Arrastia R, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Davies P, Agarwal S, Lin F, Sarkis G, Yadikar H, Yang Z, Manley GT, Wang KKW, Cooper SR, Dams-O'Connor K, Borrasso AJ, Inoue T, Maas AIR, Menon DK, Schnyer DM, Vassar MJ

Apolipoprotein E epsilon 4 (APOE-e4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.

Brain and behavior

Yue JK, Robinson CK, Burke JF, Winkler EA, Deng H, Cnossen MC, Lingsma HF, Ferguson AR, McAllister TW, Rosand J, Burchard EG, Sorani MD, Sharma S, Nielson JL, Satris GG, Talbott JF, Tarapore PE, Korley FK, Wang KKW, Yuh EL, Mukherjee P, Diaz-Arrastia R, Valadka AB, Okonkwo DO, Manley GT

Emergency department blood alcohol level associates with injury factors and six-month outcome after uncomplicated mild traumatic brain injury.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Yue JK, Ngwenya LB, Upadhyayula PS, Deng H, Winkler EA, Burke JF, Lee YM, Robinson CK, Ferguson AR, Lingsma HF, Cnossen MC, Pirracchio R, Korley FK, Vassar MJ, Yuh EL, Mukherjee P, Gordon WA, Valadka AB, Okonkwo DO, Manley GT

Selective Serotonin Reuptake Inhibitors for Treating Neurocognitive and Neuropsychiatric Disorders Following Traumatic Brain Injury: An Evaluation of Current Evidence.

Brain sciences

Yue JK, Burke JF, Upadhyayula PS, Winkler EA, Deng H, Robinson CK, Pirracchio R, Suen CG, Sharma S, Ferguson AR, Ngwenya LB, Stein MB, Manley GT, Tarapore PE

The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration To Accelerate Diagnosis and Treatment of Traumatic Brain Injury.

Journal of neurotrauma

Manley GT, Mac Donald CL, Markowitz AJ, Stephenson D, Robbins A, Gardner RC, Winkler E, Bodien YG, Taylor SR, Yue JK, Kannan L, Kumar A, McCrea MA, Wang KK

Safety and cost efficiency of a restrictive transfusion protocol in patients with traumatic brain injury.

Journal of neurosurgery

Ngwenya LB, Suen CG, Tarapore PE, Manley GT, Huang MC

Development of a Prediction Model for Post-Concussive Symptoms following Mild Traumatic Brain Injury: A TRACK-TBI Pilot Study.

Journal of neurotrauma

Cnossen MC, Winkler EA, Yue JK, Okonkwo DO, Valadka AB, Steyerberg EW, Lingsma HF, Manley GT

Morbidity and Mortality Associated with Surgery of Traumatic C2 Fractures in Octogenarians.

Neurosurgery

Dhall SS, Yue JK, Winkler EA, Mummaneni PV, Manley GT, Tarapore PE

Prehospital Intubation is Associated with Favorable Outcomes and Lower Mortality in ProTECT III.

Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors

Denninghoff KR, Nuño T, Pauls Q, Yeatts SD, Silbergleit R, Palesch YY, Merck LH, Manley GT, Wright DW

Consensus statement on concussion in sport-the 5th international conference on concussion in sport held in Berlin, October 2016.

British journal of sports medicine

McCrory P, Meeuwisse W, Dvorák J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, Davis GA, Ellenbogen R, Emery C, Engebretsen L, Feddermann-Demont N, Giza CC, Guskiewicz KM, Herring S, Iverson GL, Johnston KM, Kissick J, Kutcher J, Leddy JJ, Maddocks D, Makdissi M, Manley GT, McCrea M, Meehan WP, Nagahiro S, Patricios J, Putukian M, Schneider KJ, Sills A, Tator CH, Turner M, Vos PE

Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis.

PloS one

Nielson JL, Cooper SR, Yue JK, Sorani MD, Inoue T, Yuh EL, Mukherjee P, Petrossian TC, Paquette J, Lum PY, Carlsson GE, Vassar MJ, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Manley GT, Ferguson AR

Resting-State Functional Connectivity Alterations Associated with Six-Month Outcomes in Mild Traumatic Brain Injury.

Journal of neurotrauma

Palacios EM, Yuh EL, Chang YS, Yue JK, Schnyer DM, Okonkwo DO, Valadka AB, Gordon WA, Maas AIR, Vassar M, Manley GT, Mukherjee P

Temporal profile of care following mild traumatic brain injury: predictors of hospital admission, follow-up referral and six-month outcome.

Brain injury

Yue JK, Winkler EA, Sharma S, Vassar MJ, Ratcliff JJ, Korley FK, Seabury SA, Ferguson AR, Lingsma HF, Deng H, Meeuws S, Adeoye OM, Rick JW, Robinson CK, Duarte SM, Yuh EL, Mukherjee P, Dikmen SS, McAllister TW, Diaz-Arrastia R, Valadka AB, Gordon WA, Okonkwo DO, Manley GT

Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury.

AJNR. American journal of neuroradiology

Haefeli J, Mabray MC, Whetstone WD, Dhall SS, Pan JZ, Upadhyayula P, Manley GT, Bresnahan JC, Beattie MS, Ferguson AR, Talbott JF

DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury.

Neurogenetics

Yue JK, Winkler EA, Rick JW, Burke JF, McAllister TW, Oh SS, Burchard EG, Hu D, Rosand J, Temkin NR, Korley FK, Sorani MD, Ferguson AR, Lingsma HF, Sharma S, Robinson CK, Yuh EL, Tarapore PE, Wang KK, Puccio AM, Mukherjee P, Diaz-Arrastia R, Gordon WA, Valadka AB, Okonkwo DO, Manley GT

Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.

Neurosurgery

Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS

COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Winkler EA, Yue JK, Ferguson AR, Temkin NR, Stein MB, Barber J, Yuh EL, Sharma S, Satris GG, McAllister TW, Rosand J, Sorani MD, Lingsma HF, Tarapore PE, Burchard EG, Hu D, Eng C, Wang KK, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT

Circadian variability of the initial Glasgow Coma Scale score in traumatic brain injury patients.

Neurobiology of sleep and circadian rhythms

Yue JK, Robinson CK, Winkler EA, Upadhyayula PS, Burke JF, Pirracchio R, Suen CG, Deng H, Ngwenya LB, Dhall SS, Manley GT, Tarapore PE

Advances in Neurotrauma Research.

Neurosurgery clinics of North America

Vespa PM, Hirt D, Manley GT

Cerebral Edema in Traumatic Brain Injury: Pathophysiology and Prospective Therapeutic Targets.

Neurosurgery clinics of North America

Winkler EA, Minter D, Yue JK, Manley GT

Comparative Auditory Neuroscience: Understanding the Evolution and Function of Ears.

Journal of the Association for Research in Otolaryngology : JARO

Manley GA

Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials.

Journal of neurotrauma

Silverberg ND, Crane PK, Dams-O'Connor K, Holdnack J, Ivins BJ, Lange RT, Manley GT, McCrea M, Iverson GL

Screening for Post-Traumatic Stress Disorder in a Civilian Emergency Department Population with Traumatic Brain Injury.

Journal of neurotrauma

Haarbauer-Krupa J, Taylor CA, Yue JK, Winkler EA, Pirracchio R, Cooper SR, Burke JF, Stein MB, Manley GT

The acute respiratory distress syndrome following isolated severe traumatic brain injury.

The journal of trauma and acute care surgery

Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ

Establishing a Traumatic Brain Injury Program of Care: Benchmarking Outcomes after Institutional Adoption of Evidence-Based Guidelines.

Journal of neurotrauma

Tarapore PE, Vassar MJ, Cooper S, Lay T, Galletly J, Manley GT, Huang MC

A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury.

Journal of neuroinflammation

Lee S, Mattingly A, Lin A, Sacramento J, Mannent L, Castel MN, Canolle B, Delbary-Gossart S, Ferzaz B, Morganti JM, Rosi S, Ferguson AR, Manley GT, Bresnahan JC, Beattie MS

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury.

Brain : a journal of neurology

Delbary-Gossart S, Lee S, Baroni M, Lamarche I, Arnone M, Canolle B, Lin A, Sacramento J, Salegio EA, Castel MN, Delesque-Touchard N, Alam A, Laboudie P, Ferzaz B, Savi P, Herbert JM, Manley GT, Ferguson AR, Bresnahan JC, Bono F, Beattie MS

Adult sports-related traumatic brain injury in United States trauma centers.

Neurosurgical focus

Winkler EA, Yue JK, Burke JF, Chan AK, Dhall SS, Berger MS, Manley GT, Tarapore PE

Pediatric sports-related traumatic brain injury in United States trauma centers.

Neurosurgical focus

Yue JK, Winkler EA, Burke JF, Chan AK, Dhall SS, Berger MS, Manley GT, Tarapore PE

Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury.

Journal of neurotrauma

Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR

Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study.

Journal of neurotrauma

Wang KK, Yang Z, Yue JK, Zhang Z, Winkler EA, Puccio AM, Diaz-Arrastia R, Lingsma HF, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Manley GT, Cooper SR, Dams-O'Connor K, Hricik AJ, Inoue T, Maas AI, Menon DK, Schnyer DM, Sinha TK, Vassar MJ

COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.

Neurogenetics

Winkler EA, Yue JK, McAllister TW, Temkin NR, Oh SS, Burchard EG, Hu D, Ferguson AR, Lingsma HF, Burke JF, Sorani MD, Rosand J, Yuh EL, Barber J, Tarapore PE, Gardner RC, Sharma S, Satris GG, Eng C, Puccio AM, Wang KK, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT

Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury.

Nature communications

Nielson JL, Paquette J, Liu AW, Guandique CF, Tovar CA, Inoue T, Irvine KA, Gensel JC, Kloke J, Petrossian TC, Lum PY, Carlsson GE, Manley GT, Young W, Beattie MS, Bresnahan JC, Ferguson AR

Perioperative morbidity and mortality after lumbar trauma in the elderly.

Neurosurgical focus

Winkler EA, Yue JK, Birk H, Robinson CK, Manley GT, Dhall SS, Tarapore PE

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury.

Journal of neurotrauma

Amyot F, Arciniegas DB, Brazaitis MP, Curley KC, Diaz-Arrastia R, Gandjbakhche A, Herscovitch P, Hinds SR, Manley GT, Pacifico A, Razumovsky A, Riley J, Salzer W, Shih R, Smirniotopoulos JG, Stocker D

Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury.

Journal of neurotrauma

Korley FK, Diaz-Arrastia R, Wu AH, Yue JK, Manley GT, Sair HI, Van Eyk J, Everett AD, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Mukherjee P, Yuh EL, Lingsma HF, Puccio AM, Schnyer DM

Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome.

Journal of neurosurgery. Spine

Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS

The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings.

Journal of neurosurgery. Spine

Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS

Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice.

Glia

Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS

Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury.

Neurogenetics

Yue JK, Pronger AM, Ferguson AR, Temkin NR, Sharma S, Rosand J, Sorani MD, McAllister TW, Barber J, Winkler EA, Burchard EG, Hu D, Lingsma HF, Cooper SR, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT

Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging.

Journal of neurotrauma

McMahon PJ, Panczykowski DM, Yue JK, Puccio AM, Inoue T, Sorani MD, Lingsma HF, Maas AI, Valadka AB, Yuh EL, Mukherjee P, Manley GT, Okonkwo DO

Classification of traumatic brain injury: past, present, and future.

Handbook of clinical neurology

Hawryluk GW, Manley GT

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

Neurosurgery

Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A

Genetic data sharing and privacy.

Neuroinformatics

Sorani MD, Yue JK, Sharma S, Manley GT, Ferguson AR

Very early administration of progesterone for acute traumatic brain injury.

The New England journal of medicine

Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley GT, Merck LH, Janis LS, Barsan WG

Polyetheretherketone implants for the repair of large cranial defects: a 3-center experience.

Neurosurgery

Rosenthal G, Ng I, Moscovici S, Lee KK, Lay T, Martin C, Manley GT

Imaging concussion: a review.

Neurosurgery

Yuh EL, Hawryluk GW, Manley GT

Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: a TRACK-TBI study.

Journal of neurotrauma

Yuh EL, Cooper SR, Mukherjee P, Yue JK, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Schnyer DM, Vassar MJ, Maas AI, Manley GT

ED disposition of the Glasgow Coma Scale 13 to 15 traumatic brain injury patient: analysis of the Transforming Research and Clinical Knowledge in TBI study.

The American journal of emergency medicine

Ratcliff JJ, Adeoye O, Lindsell CJ, Hart KW, Pancioli A, McMullan JT, Yue JK, Nishijima DK, Gordon WA, Valadka AB, Okonkwo DO, Lingsma HF, Maas AI, Manley GT

The emergency department social work intervention for mild traumatic brain injury (SWIFT-Acute): a pilot study.

Brain injury

Moore M, Winkelman A, Kwong S, Segal SP, Manley GT, Shumway M

Decompressive craniectomy for acute subdural hematomas.

Journal of neurosurgery

Kolias AG, Hutchinson PJ, Menon DK, Manley GT, Gallagher CN, Servadei F

Informatics for neurocritical care: challenges and opportunities.

Neurocritical care

Sivaganesan A, Manley GT, Huang MC

Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study.

Journal of neurotrauma

McMahon P, Hricik A, Yue JK, Puccio AM, Inoue T, Lingsma HF, Beers SR, Gordon WA, Valadka AB, Manley GT, Okonkwo DO

The impact of previous traumatic brain injury on health and functioning: a TRACK-TBI study.

Journal of neurotrauma

Dams-O'Connor K, Spielman L, Singh A, Gordon WA, Lingsma HF, Maas AI, Manley GT, Mukherjee P, Okonkwo DO, Puccio AM, Schnyer DM, Valadka AB, Yue JK, Yuh EL

Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein.

Journal of neurotrauma

Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, McMahon PJ, Inoue T, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Okonkwo DO, Manley GT

Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury.

Journal of neurotrauma

Yue JK, Vassar MJ, Lingsma HF, Cooper SR, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Mukherjee P, Yuh EL, Puccio AM, Schnyer DM, Manley GT

GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study.

Journal of neurotrauma

Okonkwo DO, Yue JK, Puccio AM, Panczykowski DM, Inoue T, McMahon PJ, Sorani MD, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Manley GT

Military risk factors for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Weiner MW, Friedl KE, Pacifico A, Chapman JC, Jaffee MS, Little DM, Manley GT, McKee A, Petersen RC, Pitman RK, Yaffe K, Zetterberg H, Obana R, Bain LJ, Carrillo MC

Altering physiological networks using drugs: steps towards personalized physiology.

BMC medical genomics

Grossman AD, Cohen MJ, Manley GT, Butte AJ

Resting state magnetoencephalography functional connectivity in traumatic brain injury.

Journal of neurosurgery

Tarapore PE, Findlay AM, Lahue SC, Lee H, Honma SM, Mizuiri D, Luks TL, Manley GT, Nagarajan SS, Mukherjee P

Mosaic evolution of the mammalian auditory periphery.

Advances in experimental medicine and biology

Manley GA

Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury.

Annals of neurology

Yuh EL, Mukherjee P, Lingsma HF, Yue JK, Ferguson AR, Gordon WA, Valadka AB, Schnyer DM, Okonkwo DO, Maas AI, Manley GT

Early management of severe traumatic brain injury.

Lancet (London, England)

Rosenfeld JV, Maas AI, Bragge P, Morganti-Kossmann MC, Manley GT, Gruen RL

A longitudinal MRI study of traumatic axonal injury in patients with moderate and severe traumatic brain injury.

Journal of neurology, neurosurgery, and psychiatry

Moen KG, Skandsen T, Folvik M, Brezova V, Kvistad KA, Rydland J, Manley GT, Vik A

Coagulopathy after traumatic brain injury.

Neurosurgery

Laroche M, Kutcher ME, Huang MC, Cohen MJ, Manley GT

Quantitative CT improves outcome prediction in acute traumatic brain injury.

Journal of neurotrauma

Yuh EL, Cooper SR, Ferguson AR, Manley GT

The effect of decompressive hemicraniectomy on brain temperature after severe brain injury.

Neurocritical care

Nakagawa K, Hills NK, Kamel H, Patel PV, Manley GT, Hemphill JC

Marked reduction in wound complication rates following decompressive hemicraniectomy with an improved operative closure technique.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Sughrue ME, Bloch OG, Manley GT, Stiver SI

Temporizing treatment of hyperacute subdural hemorrhage by subdural evacuation port system placement.

Journal of neurosurgery

Flint AC, Gean AD, Manley GT, Rao VA, Sheridan WF, von Koch CS

Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research.

Journal of neurotrauma

Nakagawa A, Manley GT, Gean AD, Ohtani K, Armonda R, Tsukamoto A, Yamamoto H, Takayama K, Tominaga T

Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy.

Brain : a journal of neurology

Beattie MS, Manley GT

Dynamic, multi-level network models of clinical trials.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Sorani MD, Manley GT, Claude Hemphill J, Baranzini SE

Common data elements for research on traumatic brain injury and psychological health: current status and future development.

Archives of physical medicine and rehabilitation

Whyte J, Vasterling J, Manley GT

Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group.

Archives of physical medicine and rehabilitation

Manley GT, Diaz-Arrastia R, Brophy M, Engel D, Goodman C, Gwinn K, Veenstra TD, Ling G, Ottens AK, Tortella F, Hayes RL

Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution.

Journal of cognitive neuroscience

Voytek B, Secundo L, Bidet-Caulet A, Scabini D, Stiver SI, Gean AD, Manley GT, Knight RT

Abrupt increase in rat carotid blood flow induces rapid alteration of artery mechanical properties.

Journal of the mechanical behavior of biomedical materials

Monson KL, Matsumoto MM, Young WL, Manley GT, Hashimoto T

Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis.

Critical care (London, England)

Cohen MJ, Grossman AD, Morabito D, Knudson MM, Butte AJ, Manley GT

Interobserver variability in the assessment of CT imaging features of traumatic brain injury.

Journal of neurotrauma

Chun KA, Manley GT, Stiver SI, Aiken AH, Phan N, Wang V, Meeker M, Cheng SC, Gean AD, Wintermark M

Clinical trials in traumatic brain injury: past experience and current developments.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Maas AI, Roozenbeek B, Manley GT

Infection in the intensive care unit alters physiological networks.

BMC bioinformatics

Grossman AD, Cohen MJ, Manley GT, Butte AJ

Race\ethnicity and outcome after traumatic brain injury at a single, diverse center.

The Journal of trauma

Sorani MD, Lee M, Kim H, Meeker M, Manley GT

Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ beds.

The Journal of trauma

Wan JJ, Cohen MJ, Rosenthal G, Haitsma IK, Morabito DJ, Derugin N, Knudson MM, Manley GT

Role of aquaporin-4 in cerebral edema and stroke.

Handbook of experimental pharmacology

Zador Z, Stiver S, Wang V, Manley GT

Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury.

Brain : a journal of neurology

Niogi SN, Mukherjee P, Ghajar J, Johnson CE, Kolster R, Lee H, Suh M, Zimmerman RD, Manley GT, McCandliss BD

Biaxial response of passive human cerebral arteries.

Annals of biomedical engineering

Monson KL, Barbaro NM, Manley GT

Prehospital management of traumatic brain injury.

Neurosurgical focus

Stiver SI, Manley GT

Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury.

Journal of neurosurgery

Vik A, Nag T, Fredriksli OA, Skandsen T, Moen KG, Schirmer-Mikalsen K, Manley GT

Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI.

Journal of neurotrauma

Lee H, Wintermark M, Gean AD, Ghajar J, Manley GT, Mukherjee P

Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury.

Journal of neurosurgery

Stiver SI, Wintermark M, Manley GT

Classification of traumatic brain injury for targeted therapies.

Journal of neurotrauma

Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT

Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury.

Critical care medicine

Rosenthal G, Hemphill JC, Sorani M, Martin C, Morabito D, Obrist WD, Manley GT

Novel variants in human Aquaporin-4 reduce cellular water permeability.

Human molecular genetics

Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT

Aquaporin-4-deficient mice have increased extracellular space without tortuosity change.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yao X, Hrabetová S, Nicholson C, Manley GT

Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury.

AJNR. American journal of neuroradiology

Niogi SN, Mukherjee P, Ghajar J, Johnson C, Kolster RA, Sarkar R, Lee H, Meeker M, Zimmerman RD, Manley GT, McCandliss BD

In vitro comparison of two generations of Licox and Neurotrend catheters.

Acta neurochirurgica. Supplement

Haitsma I, Rosenthal G, Morabito D, Rollins M, Maas AI, Manley GT

Motor trephine syndrome: a mechanistic hypothesis.

Acta neurochirurgica. Supplement

Stiver SI, Wintermark M, Manley GT

Predictive values of age and the Glasgow Coma Scale in traumatic brain injury patients treated with decompressive craniectomy.

Acta neurochirurgica. Supplement

Potts MB, Chi JH, Meeker M, Holland MC, Claude HJ, Manley GT

The role of lung function in brain tissue oxygenation following traumatic brain injury.

Journal of neurosurgery

Rosenthal G, Hemphill JC, Sorani M, Martin C, Morabito D, Meeker M, Wang V, Manley GT

Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway.

The Journal of trauma

Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF

Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS

The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage.

The Journal of trauma

Smith JS, Chang EF, Rosenthal G, Meeker M, von Koch C, Manley GT, Holland MC

Aquaporins: role in cerebral edema and brain water balance.

Progress in brain research

Zador Z, Bloch O, Yao X, Manley GT

Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermia.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. IV. Infection prophylaxis.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. V. Deep vein thrombosis prophylaxis.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedatives.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. XII. Nutrition.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. XIII. Antiseizure prophylaxis.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. XIV. Hyperventilation.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

Guidelines for the management of severe traumatic brain injury. XV. Steroids.

Journal of neurotrauma

Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW

New approaches to physiological informatics in neurocritical care.

Neurocritical care

Sorani MD, Hemphill JC, Morabito D, Rosenthal G, Manley GT

Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS

Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study.

The Journal of trauma

Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, Holcroft JJ, Moncrief H, Noble J, Wisner D, Kaups KL, Bennick LD, Manley GT

Continuous muscle tissue oxygenation in critically injured patients: a prospective observational study.

The Journal of trauma

Ikossi DG, Knudson MM, Morabito DJ, Cohen MJ, Wan JJ, Khaw L, Stewart CJ, Hemphill C, Manley GT

Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Bloch O, Auguste KI, Manley GT, Verkman AS

Controlled cortical impact in swine: pathophysiology and biomechanics.

Journal of neurotrauma

Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS

Impaired pain sensation in mice lacking Aquaporin-1 water channels.

Biochemical and biophysical research communications

Oshio K, Watanabe H, Yan D, Verkman AS, Manley GT

Increased seizure duration in mice lacking aquaporin-4 water channels.

Acta neurochirurgica. Supplement

Binder DK, Yao X, Verkman AS, Manley GT

Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial.

The Journal of trauma

Livingston DH, Lavery RF, Mosenthal AC, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R

Involvement of aquaporin-4 in astroglial cell migration and glial scar formation.

Journal of cell science

Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS

K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator.

Nature methods

Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS

Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess.

Journal of neurochemistry

Bloch O, Papadopoulos MC, Manley GT, Verkman AS

Airbag deployment and improperly restrained children: a lethal combination.

The Journal of trauma

Quiñones-Hinojosa A, Jun P, Manley GT, Knudson MM, Gupta N

Evaluation of the portable infrared pupillometer.

Neurosurgery

Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley GT

Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results.

AJNR. American journal of neuroradiology

Hemphill JC, Smith WS, Sonne DC, Morabito D, Manley GT

Significance of source and size in the mechanical response of human cerebral blood vessels.

Journal of biomechanics

Monson KL, Goldsmith W, Barbaro NM, Manley GT

Expression of the aquaporin-1 water channel in human glial tumors.

Neurosurgery

Oshio K, Binder DK, Liang Y, Bollen A, Feuerstein B, Berger MS, Manley GT

Pupil examination: validity and clinical utility of an automated pupillometer.

The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G

A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patients.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

Barton CW, Hemphill JC, Morabito D, Manley G

Brain tissue oxygen monitoring in intracerebral hemorrhage.

Neurocritical care

Hemphill JC, Morabito D, Farrant M, Manley GT

Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT

Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Papadopoulos MC, Manley GT, Krishna S, Verkman AS

The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial.

The Journal of trauma

Mosenthal AC, Livingston DH, Lavery RF, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R

Volumetric proton spectroscopic imaging of mild traumatic brain injury.

AJNR. American journal of neuroradiology

Govindaraju V, Gauger GE, Manley GT, Ebel A, Meeker M, Maudsley AA

Increased seizure threshold in mice lacking aquaporin-4 water channels.

Neuroreport

Binder DK, Oshio K, Ma T, Verkman AS, Manley GT

Expression of aquaporin water channels in mouse spinal cord.

Neuroscience

Oshio K, Binder DK, Yang B, Schecter S, Verkman AS, Manley GT

Molecular mechanisms of brain tumor edema.

Neuroscience

Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS

Axial mechanical properties of fresh human cerebral blood vessels.

Journal of biomechanical engineering

Monson KL, Goldsmith W, Barbaro NM, Manley GT

Ruptured posterior communicating artery aneurysm presenting as acute subdural hematoma.

The American journal of emergency medicine

Tsao JW, Waldman JL, Manley GT

Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production.

Acta neurochirurgica. Supplement

Oshio K, Song Y, Verkman AS, Manley GT

Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema.

Acta neurochirurgica. Supplement

Oshio K, Binder DK, Bollen A, Verkman AS, Berger MS, Manley GT

Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation.

Advances in experimental medicine and biology

Manley GT, Hemphill JC, Morabito D, Erickson V, Holcroft JJ, Derugin N, Knudson MM

Computational study of the contribution of the vasculature on the dynamic response of the brain.

Stapp car crash journal

Zhang L, Bae J, Hardy WN, Monson KL, Manley GT, Goldsmith W, Yang KH, King AI

Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, Knudson MM, Manley GT

Infrared pupillometry during uncal herniation.

Journal of neurosurgical anesthesiology

Manley GT, Larson MD

Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice.

Journal of neuroscience methods

Solenov EI, Vetrivel L, Oshio K, Manley GT, Verkman AS

Hypotension, hypoxia, and head injury: frequency, duration, and consequences.

Archives of surgery (Chicago, Ill. : 1960)

Manley G, Knudson MM, Morabito D, Damron S, Erickson V, Pitts L

The ICH score: a simple, reliable grading scale for intracerebral hemorrhage.

Stroke

Hemphill JC, Bonovich DC, Besmertis L, Manley GT, Johnston SC

Cerebral oxygenation during hemorrhagic shock: perils of hyperventilation and the therapeutic potential of hypoventilation.

The Journal of trauma

Manley GT, Hemphill JC, Morabito D, Derugin N, Erickson V, Pitts LH, Knudson MM

Skeletal muscle function and water permeability in aquaporin-4 deficient mice.

American journal of physiology. Cell physiology

Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS

Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice.

Experimental physiology

Verkman AS, Yang B, Song Y, Manley GT, Ma T

Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.

Nature medicine

Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS

Brain tissue oxygenation during hemorrhagic shock, resuscitation, and alterations in ventilation.

The Journal of trauma

Manley GT, Pitts LH, Morabito D, Doyle CA, Gibson J, Gimbel M, Hopf HW, Knudson MM

Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate.

Journal of neurosurgery

Stockhammer G, Manley GT, Johnson R, Rosenblum MK, Samid D, Lieberman FS