Aric Prather, PhD

Associate Professor of Psychiatry
Committee Members

Aric Prather is an assistant professor in the UCSF Department of Psychiatry. He is also a faculty member in the Health Psychology Postdoctoral Program, the the Robert Wood Johnson Health and Society Postdoctoral Scholars Program, and on the Executive Board of the UCSF Center for Obesity Assessment, Study, and Treatment (COAST).  His research focuses on the inter-relationship between psychological stress and sleep as dynamic predictors of physical and mental health.  His research utilizes epidemiologic, naturalistic, and laboratory based studies to understand the extent to which sleep disturbance serves as a critical behavioral pathway to poor health.  With specialized training in psychoneuroimmunology (PNI), he primarily focuses on immune outcomes implicated in infectious disease, inflammatory conditions, and accelerated immunosenescence.   He is also dedicated to investigating how larger social construct (e.g, social disadvantage) drive variation in stress and sleep disturbance and ultimately contribute to health disparities.

Publications: 

Evaluation of racial and ethnic heterogeneity in the associations of sleep quality and sleep apnea risk with cognitive function and cognitive decline.

Alzheimer's & dementia (New York, N. Y.)

Chen R, Wang J, Pederson AM, Prather AA, Hirst AK, Ackley S, Hokett E, George KM, Mungas D, Mayeda ER, Gilsanz P, Haneuse S, Whitmer RA, Glymour MM

Disturbed sleep is associated with worse patient-reported outcomes and chronic lung allograft dysfunction after lung transplantation.

medRxiv : the preprint server for health sciences

Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Greenland JR, Singer JP

Estimating the effect of timing of earned income tax credit refunds on perinatal outcomes: a quasi-experimental study of California births.

BMC public health

Karasek D, Batra A, Baer RJ, Butcher BDC, Feuer S, Fuchs JD, Kuppermann M, Gomez AM, Prather AA, Pantell M, Rogers E, Snowden JM, Torres J, Rand L, Jelliffe-Pawlowski L, Hamad R

The more symptoms the better? Covid-19 vaccine side effects and long-term neutralizing antibody response.

medRxiv : the preprint server for health sciences

Dutcher EG, Epel ES, Mason AE, Hecht FM, Robinson JE, Drury SS, Prather AA

Ecological Momentary Assessment of Midlife Adults' Daily Stress: Protocol for the Stress Reports in Variable Environments (STRIVE) App Study.

JMIR research protocols

Jordan EJ, Shih PC, Nelson EJ, Carter SJ, Schootman M, Prather AA, Yao X, Peters CD, Perry CSE

Associations between klotho and telomere biology in high stress caregivers.

Aging

Brown RL, Epel EE, Lin J, Dubal DB, Prather AA

Examining Daily Associations Among Sleep, Stress, and Blood Pressure Across Adulthood.

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine

Newman DB, Gordon AM, Prather AA, Berry Mendes W

Predictors of long-term neutralizing antibody titers following COVID-19 vaccination by three vaccine types: the BOOST study.

Scientific reports

Prather AA, Dutcher EG, Robinson J, Lin J, Blackburn E, Hecht FM, Mason AE, Fromer E, Merino B, Frazier R, O'Bryan J, Drury S, Epel ES

Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health.

Policy insights from the behavioral and brain sciences

Jones EJ, Ayling K, Wiley CR, Geraghty AWA, Greer AL, Holt-Lunstad J, Prather AA, Schreier HMC, Silver RC, Sneed RS, Marsland AL, Pressman SD, Vedhara K

A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination.

Current biology : CB

Spiegel K, Rey AE, Cheylus A, Ayling K, Benedict C, Lange T, Prather AA, Taylor DJ, Irwin MR, Van Cauter E

Examining the Cross-sectional Association Between Neighborhood Conditions, Discrimination, and Telomere Length in a Predominantly African American Sample.

Journal of racial and ethnic health disparities

Troxel WM, Madrigano J, Haas AC, Dubowitz T, Rosso AL, Prather AA, Ghosh-Dastidar M, Weinstein AM, Butters MA, Presto A, Gary-Webb TL

Adverse infant outcomes among women with sleep apnea or insomnia during pregnancy: A retrospective cohort study.

Sleep health

Felder JN, Baer RJ, Rand L, Ryckman KK, Jelliffe-Pawlowski L, Prather AA

Correction to: Asymmetrical Effects of Sleep and Emotions in Daily Life.

Affective science

Newman DB, Epel ES, Coccia M, Puterman E, Prather AA

Improving the language specificity of stress in psychological and population health science.

Psychosomatic medicine

Crosswell AD, Epel ES, Mendes WB, Prather AA, Stress Measurement Network

Asymmetrical Effects of Sleep and Emotions in Daily Life.

Affective science

Newman DB, Epel ES, Coccia M, Puterman E, Prather AA

Links between the brain and body during sleep: implications for memory processing.

Trends in neurosciences

Whitehurst LN, Subramoniam A, Krystal A, Prather AA

Posttraumatic stress disorder (PTSD), sleep, and cardiovascular disease risk: A mechanism-focused narrative review.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association

Meinhausen C, Prather AA, Sumner JA

What Is Insomnia?

JAMA

Krystal AD, Ashbrook LH, Prather AA

Psychological Resources and Biomarkers of Health in the Context of Chronic Parenting Stress.

International journal of behavioral medicine

Crosswell AD, Sagui-Henson S, Prather AA, Coccia M, Irwin MR, Epel ES

The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California.

Lancet Regional Health. Americas

Karasek D, Baer RJ, McLemore MR, Bell AJ, Blebu BE, Casey JA, Coleman-Phox K, Costello JM, Felder JN, Flowers E, Fuchs JD, Gomez AM, Karvonen K, Kuppermann M, Liang L, McKenzie-Sampson S, McCulloch CE, Oltman SP, Pantell MS, Piao X, Prather AA, Schmidt RJ, Scott KA, Spellen S, Stookey JD, Tesfalul M, Rand L, Jelliffe-Pawlowski LL

A reply to Shachak.

Journal of the American Medical Informatics Association : JAMIA

Pantell MS, Adler-Milstein J, Wang MD, Prather AA, Adler NE, Gottlieb LM

"GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder.

Translational psychiatry

Protsenko E, Yang R, Nier B, Reus V, Hammamieh R, Rampersaud R, Wu GWY, Hough CM, Epel E, Prather AA, Jett M, Gautam A, Mellon SH, Wolkowitz OM

Sleep and Biological Aging: A Short Review.

Current opinion in endocrine and metabolic research

Carroll JE, Prather AA

The long shadow of childhood trauma for depression in midlife: examining daily psychological stress processes as a persistent risk pathway.

Psychological medicine

Mayer SE, Surachman A, Prather AA, Puterman E, Delucchi KL, Irwin MR, Danese A, Almeida DM, Epel ES

Temporal Links Between Self-Reported Sleep and Antibody Responses to the Influenza Vaccine.

International journal of behavioral medicine

Prather AA, Pressman SD, Miller GE, Cohen S

Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood.

Developmental psychobiology

Hamlat EJ, Prather AA, Horvath S, Belsky J, Epel ES

HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women.

Brain, behavior, and immunity

Palma-Gudiel H, Prather AA, Lin J, Oxendine JD, Guintivano J, Xia K, Rubinow DR, Wolkowitz O, Epel ES, Zannas AS

Longitudinal Associations of US Acculturation With Cognitive Performance, Cognitive Impairment, and Dementia.

American journal of epidemiology

Martinez-Miller EE, Robinson WR, Avery CL, Yang YC, Haan MN, Prather AA, Aiello AE

A call for social informatics.

Journal of the American Medical Informatics Association : JAMIA

Pantell MS, Adler-Milstein J, Wang MD, Prather AA, Adler NE, Gottlieb LM

Framework for a Community Health Observing System for the Gulf of Mexico Region: Preparing for Future Disasters.

Frontiers in public health

Sandifer P, Knapp L, Lichtveld M, Manley R, Abramson D, Caffey R, Cochran D, Collier T, Ebi K, Engel L, Farrington J, Finucane M, Hale C, Halpern D, Harville E, Hart L, Hswen Y, Kirkpatrick B, McEwen B, Morris G, Orbach R, Palinkas L, Partyka M, Porter D, Prather AA, Rowles T, Scott G, Seeman T, Solo-Gabriele H, Svendsen E, Tincher T, Trtanj J, Walker AH, Yehuda R, Yip F, Yoskowitz D, Singer B

A data-driven prospective study of dementia among older adults in the United States.

PloS one

Weiss J, Puterman E, Prather AA, Ware EB, Rehkopf DH

Measures of Psychosocial Stress and Stressful Exposures.

Arthritis care & research

Patterson SL, Sagui-Henson S, Prather AA

Anticipated and Experienced Ethnic/Racial Discrimination and Sleep: A Longitudinal Study.

Personality & social psychology bulletin

Gordon AM, Prather AA, Dover T, Espino-Pérez K, Small P, Major B

Is cellular energy monitoring more responsive to hypoxia than pulse oximetry?

Sleep & breathing = Schlaf & Atmung

Hatch GM, Ashbrook L, Prather AA, Krystal AD

Suicidal ideation and suicide attempts: associations with sleep duration, insomnia, and inflammation.

Psychological medicine

Dolsen MR, Prather AA, Lamers F, Penninx BWJH

Better together: Sleep, circadian genes, and immunity.

Brain, behavior, and immunity

Prather AA

Telomere length analysis from minimally-invasively collected samples: Methods development and meta-analysis of the validity of different sampling techniques: American Journal of Human Biology.

American journal of human biology : the official journal of the Human Biology Council

Rej PH, Bondy MH, Lin J, Prather AA, Kohrt BA, Worthman CM, Eisenberg DTA

Exposures to structural racism and racial discrimination among pregnant and early post-partum Black women living in Oakland, California.

Stress and health : journal of the International Society for the Investigation of Stress

Chambers BD, Arabia SE, Arega HA, Altman MR, Berkowitz R, Feuer SK, Franck LS, Gomez AM, Kober K, Pacheco-Werner T, Paynter RA, Prather AA, Spellen SA, Stanley D, Jelliffe-Pawlowski LL, McLemore MR

Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary.

JCI insight

Haspel JA, Anafi R, Brown MK, Cermakian N, Depner C, Desplats P, Gelman AE, Haack M, Jelic S, Kim BS, Laposky AD, Lee YC, Mongodin E, Prather AA, Prendergast BJ, Reardon C, Shaw AC, Sengupta S, Szentirmai É, Thakkar M, Walker WE, Solt LA

Part I: A Quantitative Study of Social Risk Screening Acceptability in Patients and Caregivers.

American journal of preventive medicine

De Marchis EH, Hessler D, Fichtenberg C, Adler N, Byhoff E, Cohen AJ, Doran KM, Ettinger de Cuba S, Fleegler EW, Lewis CC, Lindau ST, Tung EL, Huebschmann AG, Prather AA, Raven M, Gavin N, Jepson S, Johnson W, Ochoa E, Olson AL, Sandel M, Sheward RS, Gottlieb LM

Pregnant Patient Perceptions of Provider Detection and Treatment of Insomnia.

Behavioral sleep medicine

Felder JN, Hartman AR, Epel ES, Prather AA

Sleep debt: the impact of weekday sleep deprivation on cardiovascular health in older women.

Sleep

Cabeza de Baca T, Chayama KL, Redline S, Slopen N, Matsushita F, Prather AA, Williams DR, Buring JE, Zaslavsky AM, Albert MA

Bidirectional Links Between Social Rejection and Sleep.

Psychosomatic medicine

Gordon AM, Del Rosario K, Flores AJ, Mendes WB, Prather AA

The assessment and management of insomnia: an update.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Krystal AD, Prather AA, Ashbrook LH

Socioeconomic Status, Preeclampsia Risk and Gestational Length in Black and White Women.

Journal of racial and ethnic health disparities

Ross KM, Dunkel Schetter C, McLemore MR, Chambers BD, Paynter RA, Baer R, Feuer SK, Flowers E, Karasek D, Pantell M, Prather AA, Ryckman K, Jelliffe-Pawlowski L

Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis.

Sleep

Carroll JE, Irwin MR, Seeman TE, Diez-Roux AV, Prather AA, Olmstead R, Epel E, Lin J, Redline S

Plasma Klotho and Frailty in Older Adults: Findings From the InCHIANTI Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Shardell M, Semba RD, Kalyani RR, Bandinelli S, Prather AA, Chia CW, Ferrucci L

Sleep Pharmacogenetics: The Promise of Precision Medicine.

Sleep medicine clinics

Krystal AD, Prather AA

Association of Social and Behavioral Risk Factors With Earlier Onset of Adult Hypertension and Diabetes.

JAMA network open

Pantell MS, Prather AA, Downing JM, Gordon NP, Adler NE

Assessment of Sleep Disturbances and Exhaustion in Mothers of Children With Atopic Dermatitis.

JAMA dermatology

Ramirez FD, Chen S, Langan SM, Prather AA, McCulloch CE, Kidd SA, Cabana MD, Chren MM, Abuabara K

Association of Atopic Dermatitis With Sleep Quality in Children.

JAMA pediatrics

Ramirez FD, Chen S, Langan SM, Prather AA, McCulloch CE, Kidd SA, Cabana MD, Chren MM, Abuabara K

Cumulative lifetime stress exposure and leukocyte telomere length attrition: The unique role of stressor duration and exposure timing.

Psychoneuroendocrinology

Mayer SE, Prather AA, Puterman E, Lin J, Arenander J, Coccia M, Shields GS, Slavich GM, Epel ES

US acculturation and poor sleep among an intergenerational cohort of adult Latinos in Sacramento, California.

Sleep

Martinez-Miller EE, Prather AA, Robinson WR, Avery CL, Yang YC, Haan MN, Aiello AE

Links Between Stress, Sleep, and Inflammation: Are there Sex Differences?

Current psychiatry reports

Dolsen MR, Crosswell AD, Prather AA

The Pain of Sleep Loss: A Brain Characterization in Humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Krause AJ, Prather AA, Wager TD, Lindquist MA, Walker MP

Altered overnight levels of pro-inflammatory cytokines in men and women with posttraumatic stress disorder.

Psychoneuroendocrinology

Küffer A, Straus LD, Prather AA, Inslicht SS, Richards A, Shigenaga JK, Madden E, Metzler TJ, Neylan TC, O'Donovan A

Weight Loss Maintenance and Cellular Aging in the Supporting Health Through Nutrition and Exercise Study.

Psychosomatic medicine

Mason AE, Hecht FM, Daubenmier JJ, Sbarra DA, Lin J, Moran PJ, Schleicher SG, Acree M, Prather AA, Epel ES

Ten Surprising Facts About Stressful Life Events and Disease Risk.

Annual review of psychology

Cohen S, Murphy MLM, Prather AA

In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study.

Psychoneuroendocrinology

Lin J, Sun J, Wang S, Milush JM, Baker CAR, Coccia M, Effros RB, Puterman E, Blackburn E, Prather AA, Epel E

Associations between chronic caregiving stress and T cell markers implicated in immunosenescence.

Brain, behavior, and immunity

Prather AA, Epel ES, Portela Parra E, Coccia M, Puterman E, Aiello AE, Dhabhar FS

Mindfulness on-the-go: Effects of a mindfulness meditation app on work stress and well-being.

Journal of occupational health psychology

Bostock S, Crosswell AD, Prather AA, Steptoe A

Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity.

Journal of pediatric endocrinology & metabolism : JPEM

Wojcicki JM, Prather AA, Epel E, Wang D, Dubal DB

More than a feeling: A unified view of stress measurement for population science.

Frontiers in neuroendocrinology

Epel ES, Crosswell AD, Mayer SE, Prather AA, Slavich GM, Puterman E, Mendes WB

A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress.

Biological psychiatry

Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES

The social side of sleep: Elucidating the links between sleep and social processes.

Current directions in psychological science

Gordon AM, Mendes WB, Prather AA

Sleep Disorder Diagnosis During Pregnancy and Risk of Preterm Birth.

Obstetrics and gynecology

Felder JN, Baer RJ, Rand L, Jelliffe-Pawlowski LL, Prather AA

Effects of daily maladaptive coping on nightly sleep in mothers.

Psychology & health

Felder JN, Epel ES, Coccia M, Puterman E, Prather AA

Sexual intimacy in couples is associated with longer telomere length.

Psychoneuroendocrinology

Cabeza de Baca T, Epel ES, Robles TF, Coccia M, Gilbert A, Puterman E, Prather AA

National Academy of Medicine Social and Behavioral Measures: Associations With Self-Reported Health.

American journal of preventive medicine

Prather AA, Gottlieb LM, Giuse NB, Koonce TY, Kusnoor SV, Stead WW, Adler NE

Sleep Habits and Susceptibility to Upper Respiratory Illness: the Moderating Role of Subjective Socioeconomic Status.

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine

Prather AA, Janicki-Deverts D, Adler NE, Hall M, Cohen S

Poor Sleep Quality, Psychological Distress, and the Buffering Effect of Mindfulness Training During Pregnancy.

Behavioral sleep medicine

Felder JN, Laraia B, Coleman-Phox K, Bush N, Suresh M, Thomas M, Adler N, Epel E, Prather AA

Impact of a Mindfulness-Based Weight-Loss Intervention on Sleep Quality Among Adults with Obesity: Data from the SHINE Randomized Controlled Trial.

Journal of alternative and complementary medicine (New York, N.Y.)

Adler E, Dhruva A, Moran PJ, Daubenmier J, Acree M, Epel ES, Bacchetti P, Prather AA, Mason A, Hecht FM

Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study.

Proceedings of the National Academy of Sciences of the United States of America

Puterman E, Gemmill A, Karasek D, Weir D, Adler NE, Prather AA, Epel ES

Institute of Medicine Measures of Social and Behavioral Determinants of Health: A Feasibility Study.

American journal of preventive medicine

Giuse NB, Koonce TY, Kusnoor SV, Prather AA, Gottlieb LM, Huang LC, Phillips SE, Shyr Y, Adler NE, Stead WW

A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Swartz JR, Prather AA, Di Iorio CR, Bogdan R, Hariri AR

PER1 rs3027172 Genotype Interacts with Early Life Stress to Predict Problematic Alcohol Use, but Not Reward-Related Ventral Striatum Activity.

Frontiers in psychology

Baranger DA, Ifrah C, Prather AA, Carey CE, Corral-Frías NS, Drabant Conley E, Hariri AR, Bogdan R

Factors related to telomere length.

Brain, behavior, and immunity

Prather AA, Hecht FM, Epel ES

Behaviorally Assessed Sleep and Susceptibility to the Common Cold.

Sleep

Prather AA, Janicki-Deverts D, Hall MH, Cohen S

Exercise mitigates cumulative associations between stress and BMI in girls age 10 to 19.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association

Puterman E, Prather AA, Epel ES, Loharuka S, Adler NE, Laraia B, Tomiyama AJ

Longevity factor klotho and chronic psychological stress.

Translational psychiatry

Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB

Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women.

Brain, behavior, and immunity

Prather AA, Gurfein B, Moran P, Daubenmier J, Acree M, Bacchetti P, Sinclair E, Lin J, Blackburn E, Hecht FM, Epel ES

Anger is associated with increased IL-6 stress reactivity in women, but only among those low in social support.

International journal of behavioral medicine

Puterman E, Epel ES, O'Donovan A, Prather AA, Aschbacher K, Dhabhar FS

Sleep and antibody response to hepatitis B vaccination.

Sleep

Prather AA, Hall M, Fury JM, Ross DC, Muldoon MF, Cohen S, Marsland AL

Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms.

Brain, behavior, and immunity

Aschbacher K, Epel E, Wolkowitz OM, Prather AA, Puterman E, Dhabhar FS

Shorter leukocyte telomere length in midlife women with poor sleep quality.

Journal of aging research

Prather AA, Puterman E, Lin J, O'Donovan A, Krauss J, Tomiyama AJ, Epel ES, Blackburn EH

Ethnic differences in the effects of the DASH diet on nocturnal blood pressure dipping in individuals with high blood pressure.

American journal of hypertension

Prather AA, Blumenthal JA, Hinderliter AL, Sherwood A

Negative affective responses to a speech task predict changes in interleukin (IL)-6.

Brain, behavior, and immunity

Carroll JE, Low CA, Prather AA, Cohen S, Fury JM, Ross DC, Marsland AL

Changes in sleep quality, but not hormones predict time to postpartum depression recurrence.

Journal of affective disorders

Okun ML, Luther J, Prather AA, Perel JM, Wisniewski S, Wisner KL

Cytokine-induced depression during IFN-alpha treatment: the role of IL-6 and sleep quality.

Brain, behavior, and immunity

Prather AA, Rabinovitz M, Pollock BG, Lotrich FE

Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production.

Biological psychology

Prather AA, Marsland AL, Hall M, Neumann SA, Muldoon MF, Manuck SB

Gender differences in stimulated cytokine production following acute psychological stress.

Brain, behavior, and immunity

Prather AA, Carroll JE, Fury JM, McDade KK, Ross D, Marsland AL

Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality.

Brain, behavior, and immunity

Marsland AL, Prather AA, Petersen KL, Cohen S, Manuck SB

Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability.

Psychosomatic medicine

Marsland AL, Gianaros PJ, Prather AA, Jennings JR, Neumann SA, Manuck SB

Positive affective style covaries with stimulated IL-6 and IL-10 production in a middle-aged community sample.

Brain, behavior, and immunity

Prather AA, Marsland AL, Muldoon MF, Manuck SB