Emin Maltepe, MD, PhD

Associate Professor of Pediatrics
Children's Precision Medicine
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Publications: 

Outcomes of Very Preterm Infants Conceived with Assisted Reproductive Technologies.

The Journal of pediatrics

Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA

Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant.

Nature biotechnology

Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM

HIF-1a promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.

Scientific reports

Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA

Effect of culture conditions and method of conception on mouse live birth rate.

F&S Science

Zhuoni Xiao, Annemarie Donjacour, Royce Harner, Rhodel Simbulan, Chia-Ning Kao, Elena Ruggeri, Xiaowei Liu, Emin Maltepe, Paolo Rinaudo

Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.

Molecular human reproduction

Ruggeri E, Lira-Albarrán S, Grow EJ, Liu X, Harner R, Maltepe E, Ramalho-Santos M, Donjacour A, Rinaudo P

Defining the ATPome reveals cross-optimization of metabolic pathways.

Nature communications

Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K

Human placental trophoblast progenitor cells (hTPCs) promote angiogenesis and neurogenesis after focal cerebral ischemia in rats.

The International journal of neuroscience

Molbay M, Özaydin-Goksu E, Kipmen-Korgun D, Unal A, Ozekinci M, Cebeci E, Maltepe E, Korgun ET

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.

Redox biology

Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM

Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.

Pulmonary circulation

Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR

Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease.

Biophysical Journal

Antoni Garcia-Herreros, Rebecca J. Kameny, Terry Zhu, Jason Boehme, Gary Raff, Juan C. Lasheras, Stephen M. Black, Emin Maltepe, Sanjeev A. Datar, Jeffrey R. Fineman

Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.

Pediatric pulmonology

Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA

Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.

American journal of respiratory cell and molecular biology

Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.

Frontiers in physiology

Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T

The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.

PloS one

Abed M, Verschueren E, Budayeva H, Liu P, Kirkpatrick DS, Reja R, Kummerfeld SK, Webster JD, Gierke S, Reichelt M, Anderson KR, Newman RJ, Roose-Girma M, Modrusan Z, Pektas H, Maltepe E, Newton K, Dixit VM

Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.

Antioxidants & redox signaling

Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM

Murine trophoblast-derived and pregnancy-associated exosome-enriched extracellular vesicle microRNAs: Implications for placenta driven effects on maternal physiology.

PloS one

Stefanski AL, Martinez N, Peterson LK, Callahan TJ, Treacy E, Luck M, Friend SF, Hermesch A, Maltepe E, Phang T, Dragone LL, Winn VD

Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E

Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E

KLF2-mediated disruption of PPAR-? signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA

Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.

Cerebellum (London, England)

Nguyen V, Sabeur K, Maltepe E, Ameri K, Bayraktar O, Rowitch DH

Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR

Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures.

Reproduction (Cambridge, England)

Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P

Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.

American journal of physiology. Heart and circulatory physiology

Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E

Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.

PloS one

Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM

Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue.

Journal of developmental origins of health and disease

Simbulan RK, Liu X, Feuer SK, Maltepe E, Donjacour A, Rinaudo P

Placenta: the forgotten organ.

Annual review of cell and developmental biology

Maltepe E, Fisher SJ

HIGD1A-mediated dormancy and tumor survival.

Molecular & cellular oncology

Ameri K, Maltepe E

Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential.

PloS one

Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P

Spare hypoxia, spoil the child?

The Journal of clinical investigation

Boehme J, Maltepe E

HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.

Cell reports

Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E

LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.

The American journal of pathology

Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E

Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes.

Endocrinology

Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo PF

Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.

Cell

Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH

Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).

The FASEB Journal

Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio

Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis.

Endocrinology

Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo PF

Placental syncytium forms a biophysical barrier against pathogen invasion.

PLoS pathogens

Zeldovich VB, Clausen CH, Bradford E, Fletcher DA, Maltepe E, Robbins JR, Bakardjiev AI

Hypoxia and trophoblast differentiation: a key role for PPAR?.

Stem cells and development

Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.

PloS one

Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E

The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.

Disease models & mechanisms

Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS

ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.

PloS one

Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E

Effect of ICSI on gene expression and development of mouse preimplantation embryos.

Human Reproduction

G. Giritharan, M.W. Li, F. Di Sebastiano, F.J. Esteban, J.A. Horcajadas, K.C.K. Lloyd, A. Donjacour, E. Maltepe, P.F. Rinaudo

Effect of substrate stiffness on early mouse embryo development.

PloS one

Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P

Impaired placental nutrient transport in mice generated by in vitro fertilization.

Endocrinology

Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P

In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.

Reproductive sciences (Thousand Oaks, Calif.)

Giritharan G, Delle Piane L, Donjacour A, Esteban FJ, Horcajadas JA, Maltepe E, Rinaudo P

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.

Development (Cambridge, England)

Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross JC, Fisher SJ

Effect of ICSI on gene expression and development of mouse preimplantation embryos.

Human reproduction (Oxford, England)

Giritharan G, Li MW, Di Sebastiano F, De Sebastiano F, Esteban FJ, Horcajadas JA, Lloyd KC, Donjacour A, Maltepe E, Rinaudo PF

Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care.

Seminars in fetal & neonatal medicine

Park AM, Sanders TA, Maltepe E

Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model.

Human reproduction (Oxford, England)

Delle Piane L, Lin W, Liu X, Donjacour A, Minasi P, Revelli A, Maltepe E, Rinaudo PF

The placenta: transcriptional, epigenetic, and physiological integration during development.

The Journal of clinical investigation

Maltepe E, Bakardjiev AI, Fisher SJ

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Journal of Clinical Investigation

K. Red-Horse, J. Rivera, A. Schanz, Y. Zhou, V. Winn, M. Kapidzic, E. Maltepe, K. Okazaki, R. Kochman, K. C. Vo, L. Giudice, A. Erlebacher, J. M. McCune, C. A. Stoddart, S. J. Fisher

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

The Journal of clinical investigation

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ

Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Lymphatic research and biology

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ

Oxygen, epigenetics and stem cell fate.

Regenerative medicine

Okazaki K, Maltepe E

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.

Molecular and cellular biology

Cowden Dahl KD, Fryer BH, Mack FA, Compernolle V, Maltepe E, Adelman DM, Carmeliet P, Simon MC

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.

Development (Cambridge, England)

Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ

Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses.

Genes & development

Adelman DM, Gertsenstein M, Nagy A, Simon MC, Maltepe E

TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.

The American journal of pathology

Shiels H, Li X, Schumacker PT, Maltepe E, Padrid PA, Sperling A, Thompson CB, Lindsten T

The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.

Biochemical and biophysical research communications

Maltepe E, Keith B, Arsham AM, Brorson JR, Simon MC

HIF-1 is essential for multilineage hematopoiesis in the embryo.

Advances in experimental medicine and biology

Adelman DM, Maltepe E, Simon MC

Multilineage embryonic hematopoiesis requires hypoxic ARNT activity.

Genes & development

Adelman DM, Maltepe E, Simon MC

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

Proceedings of the National Academy of Sciences of the United States of America

Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

Mechanisms of development

Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha.

Nature

An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV, Neckers LM

Structure of the human type-I interferon gene cluster determined from a YAC clone contig.

Genomics

Díaz MO, Pomykala HM, Bohlander SK, Maltepe E, Malik K, Brownstein B, Olopade OI

Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.

Genomics

Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO