Emin Maltepe, MD, PhD

Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation.

Scientific reports

Boehme JT, Datar SA, Sun X, Gong W, Lu Q, Soto J, Smith MA, Garcia-Flores AE, Raff GW, Wang T, Maltepe E, Black SM, Fineman JR

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells.

International journal of molecular sciences

Yegambaram M, Pokharel MD, Sun X, Lu Q, Soto J, Aggarwal S, Maltepe E, Fineman JR, Wang T, Black SM

Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.

Stroke

Mike JK, White Y, Ha J, Iranmahboub A, Hawkins C, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E

Pre-eclampsia and barker's hypothesis: are we beginning to see the trees within the forest?

Pediatric research

Tsoi SM, Steurer M, Maltepe E, Fineman JR

OMX: A Novel Oxygen Delivery Biotherapeutic Improves Outcomes in an Ovine Model of Controlled Hemorrhagic Shock.

Shock (Augusta, Ga.)

Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR

The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States.

Journal of perinatology : official journal of the California Perinatal Association

Sharma M, Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA

3 Development, Function, and Pathology of the Placenta.

Avery's Diseases of the Newborn

EMIN MALTEPE, ANNA A. PENN

Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.

Children (Basel, Switzerland)

Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E

Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.

Stroke

Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Wu YW, Fineman JR, Ferriero DM, Maltepe E

Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.

Scientific reports

Sabir H, Maes E, Zweyer M, Schleehuber Y, Imam FB, Silverman J, White Y, Pang R, Pasca AM, Robertson NJ, Maltepe E, Bernis ME

Fertility treatment increases the risk of preterm birth independent of multiple gestations.

F&S Reports

Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA

Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases.

Circulation

Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Alejandro E Garcia, Evgeny A Zemskov, Emin Maltepe, Jeffrey R Fineman, Kim Tieu, Ting Wang, Stephen M Black

Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.

American journal of obstetrics and gynecology

Redline RW, Roberts DJ, Parast MM, Ernst LM, Morgan TK, Greene MF, Gyamfi-Bannerman C, Louis JM, Maltepe E, Mestan KK, Romero R, Stone J

Defining longer term outcomes in an ovine model of moderate perinatal hypoxia-ischemia.

Developmental neuroscience

Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JV, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E

Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases.

Free Radical Biology and Medicine

Wojciech Ornatowski, Qing Lu, Xutong Sun, Alejandro Garcia Flores, Anlin Feng, Evgeny Zemskov, Emin Maltepe, Jeffrey Fineman, Ting Wang, Stephen Black

Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species.

Jason Boehme, Emin Maltepe

Outcomes of Very Preterm Infants Conceived with Assisted Reproductive Technologies.

The Journal of pediatrics

Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA

Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant.

Nature biotechnology

Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM

HIF-1a promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.

Scientific reports

Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA

Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.

Molecular human reproduction

Ruggeri E, Lira-Albarrán S, Grow EJ, Liu X, Harner R, Maltepe E, Ramalho-Santos M, Donjacour A, Rinaudo P

Effect of culture conditions and method of conception on mouse live birth rate.

F&S Science

Xiao Z, Donjacour A, Harner R, Simbulan R, Kao CN, Ruggeri E, Liu X, Maltepe E, Rinaudo P

Defining the ATPome reveals cross-optimization of metabolic pathways.

Nature communications

Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K

Human placental trophoblast progenitor cells (hTPCs) promote angiogenesis and neurogenesis after focal cerebral ischemia in rats.

The International journal of neuroscience

Molbay M, Özaydin-Goksu E, Kipmen-Korgun D, Unal A, Ozekinci M, Cebeci E, Maltepe E, Korgun ET

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.

Redox biology

Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM

Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.

Pulmonary circulation

Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR

Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease.

Biophysical Journal

Antoni Garcia-Herreros, Rebecca J. Kameny, Terry Zhu, Jason Boehme, Gary Raff, Juan C. Lasheras, Stephen M. Black, Emin Maltepe, Sanjeev A. Datar, Jeffrey R. Fineman

Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.

Pediatric pulmonology

Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA

Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.

American journal of respiratory cell and molecular biology

Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.

Frontiers in physiology

Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T

The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.

PloS one

Abed M, Verschueren E, Budayeva H, Liu P, Kirkpatrick DS, Reja R, Kummerfeld SK, Webster JD, Gierke S, Reichelt M, Anderson KR, Newman RJ, Roose-Girma M, Modrusan Z, Pektas H, Maltepe E, Newton K, Dixit VM

Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.

Antioxidants & redox signaling

Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM

Murine trophoblast-derived and pregnancy-associated exosome-enriched extracellular vesicle microRNAs: Implications for placenta driven effects on maternal physiology.

PloS one

Stefanski AL, Martinez N, Peterson LK, Callahan TJ, Treacy E, Luck M, Friend SF, Hermesch A, Maltepe E, Phang T, Dragone LL, Winn VD

Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E

Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E

KLF2-mediated disruption of PPAR-? signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA

Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.

Cerebellum (London, England)

Nguyen V, Sabeur K, Maltepe E, Ameri K, Bayraktar O, Rowitch DH

5 Development, Function, and Pathology of the Placenta.

Emin Maltepe, Anna A. Penn

Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR

Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures.

Reproduction (Cambridge, England)

Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P

Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.

American journal of physiology. Heart and circulatory physiology

Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E

Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.

PloS one

Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM

Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue.

Journal of developmental origins of health and disease

Simbulan RK, Liu X, Feuer SK, Maltepe E, Donjacour A, Rinaudo P

Placenta: the forgotten organ.

Annual review of cell and developmental biology

Maltepe E, Fisher SJ

Abstract 640: PASMC Hyperproliferation and Metabolic Shift in a Model of Pulmonary Overcirculation.

Arteriosclerosis Thrombosis and Vascular Biology

Jason Boehme, Kathryn Tormos, Jeff Fineman, Emin Maltepe

HIGD1A-mediated dormancy and tumor survival.

Molecular & cellular oncology

Ameri K, Maltepe E

Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential.

PloS one

Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P

Spare hypoxia, spoil the child?

The Journal of clinical investigation

Boehme J, Maltepe E

HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.

Cell reports

Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E

LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.

The American journal of pathology

Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E

Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes.

Endocrinology

Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo PF

Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.

Cell

Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH

Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).

The FASEB Journal

Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio

Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis.

Endocrinology

Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo PF

Placental syncytium forms a biophysical barrier against pathogen invasion.

PLoS pathogens

Zeldovich VB, Clausen CH, Bradford E, Fletcher DA, Maltepe E, Robbins JR, Bakardjiev AI

Hypoxia and trophoblast differentiation: a key role for PPAR?.

Stem cells and development

Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.

PloS one

Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E

The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.

Disease models & mechanisms

Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS

ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.

PloS one

Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E

Effect of ICSI on gene expression and development of mouse preimplantation embryos.

Human Reproduction

G. Giritharan, M.W. Li, F. Di Sebastiano, F.J. Esteban, J.A. Horcajadas, K.C.K. Lloyd, A. Donjacour, E. Maltepe, P.F. Rinaudo

Effect of substrate stiffness on early mouse embryo development.

PloS one

Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P

Impaired placental nutrient transport in mice generated by in vitro fertilization.

Endocrinology

Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P

In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.

Reproductive sciences (Thousand Oaks, Calif.)

Giritharan G, Delle Piane L, Donjacour A, Esteban FJ, Horcajadas JA, Maltepe E, Rinaudo P

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.

Development (Cambridge, England)

Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross JC, Fisher SJ

Effect of ICSI on gene expression and development of mouse preimplantation embryos.

Human reproduction (Oxford, England)

Giritharan G, Li MW, Di Sebastiano F, De Sebastiano F, Esteban FJ, Horcajadas JA, Lloyd KC, Donjacour A, Maltepe E, Rinaudo PF

Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care.

Seminars in fetal & neonatal medicine

Park AM, Sanders TA, Maltepe E

Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model.

Human reproduction (Oxford, England)

Delle Piane L, Lin W, Liu X, Donjacour A, Minasi P, Revelli A, Maltepe E, Rinaudo PF

Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Lymphatic research and biology

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ

The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells.

Somatic cell and molecular genetics

Porterfield BW, Pomykala H, Maltepe E, Bohlander SK, Rowley JD, Diaz MO

Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.

Genomics

Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO

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Emin Maltepe, MD, PhD