Emin Maltepe, MD, PhD

Associate Professor of Pediatrics

Children's Precision Medicine

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[email protected]

https://profiles.ucsf.edu/emin.maltepe

Publications:

Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

KLF2-mediated Disruption of PPAR? Signaling in Lymphatic Endothelial Cells Exposed to Chronically Increased Pulmonary Lymph Flow.

Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.

Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.

Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures.

Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.

Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.

Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue.

Placenta: the forgotten organ.

HIGD1A-mediated dormancy and tumor survival.

Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential.

Spare hypoxia, spoil the child?

HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.

LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.

Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes.

Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.

Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis.

Placental syncytium forms a biophysical barrier against pathogen invasion.

Hypoxia and trophoblast differentiation: a key role for PPAR?.

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.

The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.

ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.

Effect of substrate stiffness on early mouse embryo development.

Impaired placental nutrient transport in mice generated by in vitro fertilization.

In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.

Effect of ICSI on gene expression and development of mouse preimplantation embryos.

Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care.

Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model.

The placenta: transcriptional, epigenetic, and physiological integration during development.

Oxygen in health and disease: regulation of oxygen homeostasis--clinical implications.

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Oxygen, epigenetics and stem cell fate.

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.

Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses.

TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.

The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.

HIF-1 is essential for multilineage hematopoiesis in the embryo.

Multilineage embryonic hematopoiesis requires hypoxic ARNT activity.

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development.

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha.

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.