Keith Yamamoto, PhD

Vice Chancellor of Science Policy and Strategy
Professor of Cellular Molecular Pharmacology
Director, UCSF Precision Medicine
Leadership

As UCSF’s first vice chancellor for Science Policy and Strategy, Keith Yamamoto leads efforts to anticipate the needs of an increasingly dynamic biomedical research endeavor, and to position UCSF optimally, by working within the University as well as influencing and shaping science policy at the state and national levels and beyond.

Throughout his career, Yamamoto has been focused on the practice of science, science education and mentoring, peer review, communication of science, and advocacy for federal support for research. He also directs a basic research lab, making groundbreaking discoveries focused on signaling and transcriptional regulation by nuclear receptors.

Yamamoto has long been a voice for science policy that emphasizes integration at three levels: 1) basic, clinical and social/behavioral/population research; 2) a merging of the concepts and approaches of physical sciences, engineering and computation/math with those of the life sciences; and 3) effective partnerships between academia, industry and government. He believes that such integration will produce transformative scientific advances with potential to address urgent societal challenges.

After earning his PhD from Princeton University, Yamamoto joined the UCSF faculty in 1976. He has served in several significant leadership roles including chair of the Department of Cellular and Molecular Pharmacology, vice dean for research in the School of Medicine, and vice chancellor for research. He chaired the committee that led the planning of the UCSF Mission Bay campus.

Yamamoto has chaired or served on numerous national committees focusing on a wide range of areas (i.e., public and scientific policy, public understanding and support of biological research, science education, training the biomedical workforce, research funding, and the process of peer review at the NIH). He chairs the Coalition for the Life Sciences and sits on both the National Academy of Medicine Executive Committee and the National Academy of Sciences Division of Earth and Life Studies Advisory Committee. As Chair of the NAS Board on Life Sciences, he created the study committee that produced Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease, the report that enunciated the precision medicine concept, and he has helped lead efforts to implement it at the state and national level as well as at UCSF.

He is an elected member of the National Academy of Sciences, National Academy of Medicine, American Academy of Arts and Sciences, and American Academy of Microbiology, and is a fellow of the American Association for the Advancement of Science.

Publications: 

Time for NIH to lead on data sharing.

Science (New York, N.Y.)

Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.

Leukemia

Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

Nature

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M

Internship Experiences Contribute to Confident Career Decision Making for Doctoral Students in the Life Sciences.

CBE life sciences education

Schnoes AM, Caliendo A, Morand J, Dillinger T, Naffziger-Hirsch M, Moses B, Gibeling JC, Yamamoto KR, Lindstaedt B, McGee R, O'Brien TC

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation.

Nucleic acids research

Love MI, Huska MR, Jurk M, Schöpflin R, Starick SR, Schwahn K, Cooper SB, Yamamoto KR, Thomas-Chollier M, Vingron M, Meijsing SH

Metabolic gatekeeper function of B-lymphoid transcription factors.

Nature

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M

Glucocorticoid receptor control of transcription: precision and plasticity via allostery.

Nature reviews. Molecular cell biology

Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR

Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C).

The Journal of biological chemistry

Pack LR, Yamamoto KR, Fujimori DG

Precision medicine: Beyond the inflection point.

Science translational medicine

Hawgood S, Hook-Barnard IG, O'Brien TC, Yamamoto KR

Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms.

Advances in experimental medicine and biology

Granner DK, Wang JC, Yamamoto KR

Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes.

Genome biology

Schiller BJ, Chodankar R, Watson LC, Stallcup MR, Yamamoto KR

Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses.

PloS one

Ward JD, Mullaney B, Schiller BJ, He LD, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR

Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner.

Proceedings of the National Academy of Sciences of the United States of America

Chodankar R, Wu DY, Schiller BJ, Yamamoto KR, Stallcup MR

Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development.

PLoS genetics

Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR

A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms.

Proceedings of the National Academy of Sciences of the United States of America

Thomas-Chollier M, Watson LC, Cooper SB, Pufall MA, Liu JS, Borzym K, Vingron M, Yamamoto KR, Meijsing SH

The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals.

Nature structural & molecular biology

Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto KR

Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action.

Proceedings of the National Academy of Sciences of the United States of America

Chen SH, Masuno K, Cooper SB, Yamamoto KR

Occupancy of chromatin organizers in the Epstein-Barr virus genome.

Virology

Holdorf MM, Cooper SB, Yamamoto KR, Miranda JJ

A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression.

Molecular cancer research : MCR

Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR

Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes.

Journal of immunology (Baltimore, Md. : 1950)

Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto KR, Leitman DC

Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate.

The Journal of biological chemistry

Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ

Reciprocal intronic and exonic histone modification regions in humans.

Nature structural & molecular biology

Huff JT, Plocik AM, Guthrie C, Yamamoto KR

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

Genome research

DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD

Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network.

Molecular systems biology

Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJ

Nuclear hormone receptors in nematodes: evolution and function.

Molecular and cellular endocrinology

Taubert S, Ward JD, Yamamoto KR

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases.

Endocrine reviews

Beck IM, Vanden Berghe W, Vermeulen L, Yamamoto KR, Haegeman G, De Bosscher K

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis.

Proceedings of the National Academy of Sciences of the United States of America

So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ

DNA binding site sequence directs glucocorticoid receptor structure and activity.

Science (New York, N.Y.)

Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR

Non-competitive androgen receptor inhibition in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI

Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro.

Molecular biology of the cell

Pantoja C, Huff JT, Yamamoto KR

Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes.

Proceedings of the National Academy of Sciences of the United States of America

So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR

The Mediator subunit MDT-15 confers metabolic adaptation to ingested material.

PLoS genetics

Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.

Proceedings of the National Academy of Sciences of the United States of America

Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV

Cell- and gene-specific regulation of primary target genes by the androgen receptor.

Genes & development

Bolton EC, So AY, Chaivorapol C, Haqq CM, Li H, Yamamoto KR

Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor.

PLoS genetics

So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto KR

The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release.

Molecular and cellular biology

Meijsing SH, Elbi C, Luecke HF, Hager GL, Yamamoto KR

Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.

Proceedings of the National Academy of Sciences of the United States of America

Feldman BJ, Streeper RS, Farese RV, Yamamoto KR

Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity.

Genes & development

Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto KR

A new era in the ethics of human embryonic stem cell research.

Stem cells (Dayton, Ohio)

Lo B, Zettler P, Cedars MI, Gates E, Kriegstein AR, Oberman M, Reijo Pera R, Wagner RM, Wuerth MT, Wolf LE, Yamamoto KR

A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49.

Proceedings of the National Academy of Sciences of the United States of America

Van Gilst MR, Hadjivassiliou H, Yamamoto KR

Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans.

PLoS biology

Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR

Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.

Proceedings of the National Academy of Sciences of the United States of America

Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR

Bankrolling stem-cell research with California dollars.

The New England journal of medicine

Yamamoto KR

Identification of C. elegans DAF-12-binding sites, response elements, and target genes.

Genes & development

Shostak Y, Van Gilst MR, Antebi A, Yamamoto KR

Informed consent in human oocyte, embryo, and embryonic stem cell research.

Fertility and sterility

Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto KR

Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.

Molecular biology of the cell

Tee MK, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, Christy RJ, Yamamoto KR, Leitman DC

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor.

Proceedings of the National Academy of Sciences of the United States of America

Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ, Yamamoto KR

Medicine. Consent from donors for embryo and stem cell research.

Science (New York, N.Y.)

Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, Wolf L, Yamamoto KR

Statement on scientific publication and security.

Science (New York, N.Y.)

Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R, Rosengard A, Salzburg S, Scanlan M, Shenk T, Tabor H, Varmus H, Wimmer E, Yamamoto K

Statement on the consideration of biodefence and biosecurity.

Nature

Atlas R, Campbell P, Cozzarelli NR, Curfman G, Enquist L, Fink G, Flanagin A, Fletcher J, George E, Hammes G, Heyman D, Inglesby T, Kaplan S, Kennedy D, Krug J, Levinson R, Marcus E, Metzger H, Morse SS, O'Brien A, Onderdonk A, Poste G, Renault B, Rich R, Rosengard A, Salzberg S, Scanlan M, Shenk T, Tabor H, Varmus H, Wimmer E, Yamamoto K

Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts.

Proceedings of the National Academy of Sciences of the United States of America

Rogatsky I, Luecke HF, Leitman DC, Yamamoto KR

Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA.

Journal of molecular biology

van Tilborg MA, Lefstin JA, Kruiskamp M, Teuben J, Boelens R, Yamamoto KR, Kaptein R

Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health.

Science (New York, N.Y.)

Alberts BM, Ayala FJ, Botstein D, Frank E, Holmes EW, Lee RD, Macagno ER, Marrack P, Oparil S, Orkin SH, Rubenstein AH, Slayman CW, Sparling PF, Squire LR, von Hippel PH, Yamamoto KR

Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation.

Molecular and cellular biology

Miller ME, Cairns BR, Levinson RS, Yamamoto KR, Engel DA, Smith MM

Hold 'em and fold 'em: chaperones and signal transduction.

Science (New York, N.Y.)

Bohen SP, Kralli A, Yamamoto KR

Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations.

Journal of molecular biology

van Tilborg MA, Bonvin AM, Hård K, Davis AL, Maler B, Boelens R, Yamamoto KR, Kaptein R

Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

The Journal of biological chemistry

Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS

The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors.

Molecular endocrinology (Baltimore, Md.)

Amero SA, Kretsinger RH, Moncrief ND, Yamamoto KR, Pearson WR

1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element.

Biochemistry

Remerowski ML, Kellenbach E, Boelens R, van der Marel GA, van Boom JH, Maler BA, Yamamoto KR, Kaptein R

Creation of "super" glucocorticoid receptors by point mutations in the steroid binding domain.

The Journal of biological chemistry

Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.

Nature

Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB

Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements.

Journal of biomolecular NMR

Kellenbach E, Härd T, Boelens R, Dahlman K, Carlstedt-Duke J, Gustafsson JA, van der Marel GA, van Boom JH, Maler B, Yamamoto KR

Vectors for constitutive and inducible gene expression in yeast.

Methods in enzymology

Schena M, Picard D, Yamamoto KR

Mapping the HSP90 binding region of the glucocorticoid receptor.

The Journal of biological chemistry

Howard KJ, Holley SJ, Yamamoto KR, Distelhorst CW

Solution structure of the glucocorticoid receptor DNA-binding domain.

Science (New York, N.Y.)

Härd T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Freedman LP, Carlstedt-Duke J, Yamamoto KR, Gustafsson JA, Kaptein R

More fingers in hand.

Cell

Freedman LP, Yamamoto KR, Luisi BF, Sigler PB